Currently browsing: Cardiovascular Research Cluster

Warren, Junco; Johnson, Daniel M.; Paneni, Francesco and Mathiyalagan, Prabhu (2024). [Editorial] Emerging molecular mechanisms in cardiovascular physiology and pathology. Frontiers in physiology, 15, article no. 1485595.

• Download Published Version (PDF / 526kB)

Johnson, D. M; O'Brien, S.; Holmes, A.; O'Shea, C.; Kabir, S. N; O'Reilly, M.; Avezzu, A.; Reyat, J.; Hall, A.; Apicella, C.; Ellinor, P.; Niederer, S.; Tucker, N.; Fabritz, L.; Kirchhof, P. and Pavlovic, D. (2022). Altered biophysical properties of atrial sodium channels increase flecainide effectiveness. Acta Physiologica, 236(S725)

Johnson, Daniel and Pavlovic, Davor (2022). What is actually preserved in HFpEF? Focus on myocyte calcium handling remodelling. Journal of Molecular and Cellular Cardiology, 170 pp. 115–116.

• Download Accepted Manuscript (PDF / 388kB)

Miry, Seyed Ziaedin; Zanoni, Marco A.B.; Rashwan, Tarek L.; Torero, José L. and Gerhard, Jason I. (2022). Investigation of multi-dimensional transfer effects in applied smouldering systems: A 2D numerical modelling approach. Combustion and Flame, 246, article no. 112385.

• Download Accepted Manuscript (PDF / 4MB)
• Download Supplementary Material (PDF / 1MB)

O' Brien, Sian; Holmes, Andrew P.; Johnson, Daniel M.; Kabir, S. Nashitha; O' Shea, Christopher; O' Reilly, Molly; Avezzu, Adelisa; Reyat, Jasmeet S.; Hall, Amelia W.; Apicella, Clara; Ellinor, Patrick T.; Niederer, Steven; Tucker, Nathan R.; Fabritz, Larissa; Kirchhof, Paulus and Pavlovic, Davor (2022). Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels. Journal of Molecular and Cellular Cardiology(166) pp. 23–35.

• Download Accepted Manuscript (PDF / 1MB)

Lorusso, Roberto; Belliato, Mirko; Mazzeffi, Michael; Di Mauro, Michele; Taccone, Fabio Silvio; Parise, Orlando; Albanawi, Ayat; Nandwani, Veena; McCarthy, Paul; Kon, Zachary; Menaker, Jay; Johnson, Daniel M.; Gelsomino, Sandro and Herr, Daniel (2021). Neurological complications during veno-venous extracorporeal membrane oxygenation: Does the configuration matter? A retrospective analysis of the ELSO database. Critical Care, 25(1), article no. 107.

• Download Published Version (PDF / 802kB)

Bennasar, Mohamed; Banks, Duncan; Price, Blaine and Kardos, Attila (2020). Minimal Patients’ Clinical Variables to Accurately Predict Stress Echocardiography Outcome: Validation Study Using Machine Learning Techniques. JMIR Cardio, 4(1), article no. e16975.

• Download Published Version (PDF / 380kB)

Bonacchi, Massimo; Prifti, Edvin; Bugetti, Marco; Cabrucci, Francesco; Cresci, Michael; Lucá, Fabiana; Parise, Orlando; Matteucci, Francesco; Sani, Guido; Johnson, Daniel M. and Gelsomino, Sandro (2020). In situ skeletonized bilateral thoracic artery for left coronary circulation: a 20-year experience. European Journal of Cardio-Thoracic Surgery, 57(1) pp. 160–167.

Bootman, Martin D. and Bultynck, Geert (2020). Fundamentals of Cellular Calcium Signaling: A Primer. Cold Spring Harbor Perspectives in Biology, 12, article no. a038802.

• Download Published Version (PDF / 1MB)

Dries, Eef; Amoni, Matthew; Vandenberk, Bert; Johnson, Daniel M.; Gilbert, Guillaume; Nagaraju, Chandan K.; Puertas, Rosa Doñate; Abdesselem, Mouna; Santiago, Demetrio J.; Roderick, H. Llewelyn; Claus, Piet; Willems, Rik and Sipido, Karin R. (2020). Altered adrenergic response in myocytes bordering a chronic myocardial infarction underlies in vivo triggered activity and repolarization instability. The Journal of Physiology, 598(14) pp. 2875–2895.

• Download Published Version (PDF / 5MB)

Masoud, Said; McDonald, Fraser; Bister, Dirk; Kotecki, Claire; Bootman, Martin D. and Rietdorf, Katja (2020). Examining Cardiomyocyte Dysfunction Using Acute Chemical Induction of an Ageing Phenotype. International Journal of Molecular Sciences, 21(1), article no. 197.

• Download Published Version (PDF / 12MB)

Micali, Linda R.; Qadrouh, Mohammad N.; Parise, Orlando; Parise, Gianmarco; Matteucci, Francesco; Jong, Monique; Tetta, Cecilia; Moula, Amalia I.; Johnson, Daniel M. and Gelsomino, Sandro (2020). Papillary muscle intervention vs mitral ring annuloplasty in ischemic mitral regurgitation. Journal of Cardiac Surgery, 35(3) pp. 645–653.

• Download Published Version (PDF / 885kB)

O'Shea, Christopher; Winter, James; Holmes, Andrew P.; Johnson, Daniel M.; Correia, Joao N.; Kirchhof, Paulus; Fabritz, Larissa; Rajpoot, Kashif and Pavlovic, Davor (2020). Temporal irregularity quantification and mapping of optical action potentials using wave morphology similarity. Progress in Biophysics and Molecular Biology, 157 pp. 84–93.

• Download Published Version (PDF / 2MB)

Rietdorf, Katja; Coode, Emily E.; Schulz, Angela; Wibbeler, Eva; Bootman, Martin D. and Ostergaard, John R. (2020). Cardiac pathology in neuronal ceroid lipofuscinoses (NCL): More than a mere co-morbidity. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1866(9), article no. 165643.

• Download Accepted Manuscript (PDF / 1MB)

Camparini, Luca (2019). Growth Differentiation Factor 11 and Myostatin: Mechanism and Therapeutic Role in Cardiovascular Diseases. PhD thesis The Open University.

• Download Final Version (PDF / 4MB)

Coode, Emily; McDonald, Fraser; Bister, Dirk; Bootman, Martin and Rietdorf, Katja (2019). Broken Hearts in Juvenile Dementia: investigating cardiac myocytes in CLN3 disease. In: Gordon Conference on Lysosomal Diseases, 3-8 Mar 2019, Galveston, Texas.

Crasto, Silvia (2019). Induced Pluripotent Stem Cells Technology For Investigating Familial Dilated Cardiomyopathy Due To Lamin A/C Mutations. PhD thesis The Open University.

• Download Final Version (PDF / 22MB)

Deckx, Sophie; Johnson, Daniel M.; Rienks, Marieke; Carai, Paolo; Van Deel, Elza; Van der Velden, Jolanda; Sipido, Karin R.; Heymans, Stephane and Papageorgiou, Anna-Pia (2019). Extracellular SPARC increases cardiomyocyte contraction during health and disease. PLOS ONE, 14(4), article no. e0209534.

• Download Published Version (PDF / 4MB)

Gelsomino, Sandro; Bidar, Elham; Jainandunsing, Jayant S.; Tielliu, Ignace F. J.; Lorusso, Roberto; Johnson, Daniel; Maessen, Jos G. and Natour, Ehsan (2019). Modified Gott shunt to avoid left ventricular overload and cerebral hypoperfusion during distal aortic arch surgery. Journal of Vascular Surgery Cases and Innovative Techniques, 5(1) pp. 65–67.

• Download Published Version (PDF / 776kB)

Gelsomino, Sandro; Bonacchi, Massimo; Lucà, Fabiana; Barili, Fabio; Del Pace, Stefano; Parise, Orlando; Johnson, Daniel M. and Gulizia, Michele Massimo (2019). Comparison between three different equations for the estimation of glomerular filtration rate in predicting mortality after coronary artery bypass. BMC Nephrology, 20, article no. 371.

• Download Published Version (PDF / 2MB)

Jainandunsing, Jayant S.; Linnemann, Ralph; Bouma, Wobbe; Natour, Nicole; Bidar, Elham; Lorusso, Roberto; Gelsomino, Sandro; Johnson, Daniel M. and Natour, Ehsan (2019). Aorto-atrial fistula formation and closure: a systematic review. Journal of Thoracic Disease, 11(3) pp. 1031–1046.

• Download Published Version (PDF / 1MB)

Jainandunsing, Jayant S.; Linnemann, Ralph; Maessen, Jos; Natour, Nicole E.; Lorusso, Roberto; Gelsomin, Sandro; Johnson, Daniel M. and Natour, Ehsan (2019). Aorto-atrial fistula formation and therapy. Journal of Thoracic Disease, 11(3) pp. 1016–1021.

• Download Published Version (PDF / 682kB)

Johnson, Daniel M.; Lozekoot, Pieter; Jong, Monique; Parise, Orlando; Makhoul, Maged; Matteucci, Francesco; Lucà, Fabiana; Maessen, Jos G. and Gelsomino, Sandro (2019). Superior mesenteric and renal flow patterns during intra‐aortic counterpulsation. Experimental Physiology, 104(5) pp. 643–653.

Johnson, Daniel M.; Mugelli, Alessandro and Cerbai, Elisabetta (2019). Editorial: The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias. Frontiers in Physiology, 10, article no. 1.

• Download Published Version (PDF / 175kB)

Marston, Hannah R; Hadley, Robin; Banks, Duncan and del Carmen Miranda Duro, María (2019). Mobile Self-monitoring ECG Devices to Diagnose Arrhythmia (AR) that coincide with Palpitations: A Scoping Review. Healthcare, 7(3), article no. 96.

• Download Published Version (PDF / 488kB)

Mazzeffi, Michael; Kon, Zachary; Menaker, Jay; Johnson, Daniel M.; Parise, Orlando; Gelsomino, Sandro; Lorusso, Roberto and Herr, Daniel (2019). Large Dual-Lumen Extracorporeal Membrane Oxygenation Cannulas Are Associated with More Intracranial Hemorrhage. ASAIO Journal, 65(7) pp. 674–677.

Montalti, Alice; Belliato, Mirko; Gelsomino, Sandro; Nalon, Sandro; Matteucci, Francesco; Parise, Orlando; de Jong, Monique; Makhoul, Maged; Johnson, Daniel M. and Lorusso, Roberto (2019). Continuous monitoring of membrane lung carbon dioxide removal during ECMO: experimental testing of a new volumetric capnometer. Perfusion, 34(7) pp. 538–543.

O’Shea, Christopher; Holmes, Andrew P.; Yu, Ting Y.; Winter, James; Wells, Simon P.; Parker, Beth A.; Fobian, Dannie; Johnson, Daniel M.; Correia, Joao; Kirchhof, Paulus; Fabritz, Larissa; Rajpoot, Kashif and Pavlovic, Davor (2019). High-Throughput Analysis of Optical Mapping Data Using ElectroMap. Journal of Visualized Experiments(148), article no. e59663.

• Download Published Version (PDF / 709kB)

Rietdorf, K.; Coode, E.; McDonald, F.; Bister, D.; Cooper, J.D. and Bootman, M. (2019). Ultrastructural changes in hearts from CLN3 mice. In: Gordon Conference on Lysosomal Diseases, 3-8 Mar 2019, Galveston, Texas.

ter Bekke, Rachel M. A.; Moers, Annerie M. E.; de Jong, Monique M. J.; Johnson, Daniel M.; Schwartz, Peter J.; Vanoli, Emilio and Volders, Paul G. A. (2019). Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1. International Journal of Cardiology, 286 pp. 66–72.

• Download Published Version (PDF / 1MB)

Tetta, Cecilia; Moula, Amalia Ioanna; Matteucci, Francesco; Parise, Orlando; Maesen, Bart; Johnson, Daniel; La Meir, Mark and Gelsomino, Sandro (2019). Association between atrial fibrillation and Helicobacter pylori. Clinical Research in Cardiology, 108(7) pp. 730–740.

• Download Published Version (PDF / 1MB)

Arvanitis, Demetrios A.; Vafiadaki, Elizabeth; Johnson, Daniel M.; Kranias, Evangelia G. and Sanoudou, Despina (2018). The Histidine-Rich Calcium Binding Protein in Regulation of Cardiac Rhythmicity. Frontiers in Physiology, 9, article no. 1379.

• Download Published Version (PDF / 834kB)

Ballmer-Hofer, Kurt; Hyde, Caroline A.C.; Schleier, Thomas and Avramovic, Dragana (2018). ScFvs as Allosteric Inhibitors of VEGFR-2: Novel Tools to Harness VEGF Signaling. International Journal of Molecular Sciences, 19(5), article no. 1334.

• Download Published Version (PDF / 2MB)

Bonacchi, Massimo; Prifti, Edvin; Bugetti, Marco; Parise, Orlando; Sani, Guido; Johnson, Daniel M.; Cabrucci, Francesco and Gelsomino, Sandro (2018). Deep sternal infections after in situ bilateral internal thoracic artery grafting for left ventricular myocardial revascularization: predictors and influence on 20-year outcomes. Journal of Thoracic Disease, 10(9) pp. 5208–5221.

• Download Published Version (PDF / 1MB)

Bootman, Martin D.; Allman, Sarah; Rietdorf, Katja and Bultynck, Geert (2018). Deleterious effects of calcium indicators within cells; an inconvenient truth. Cell Calcium, 73 pp. 82–87.

• Download Accepted Manuscript (PDF / 730kB)
• Download Published Version (PDF / 808kB)

Dautova, Yana; Kapustin, Alexander N.; Pappert, Kevin; Epple, Matthias; Okkenhaug, Hanneke; Cook, Simon J.; Shanahan, Catherine M.; Bootman, Martin D. and Proudfoot, Diane (2018). Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release. Journal of Molecular and Cellular Cardiology, 115 pp. 82–93.

• Download Published Version (PDF / 907kB)

de Jong, Monique M.; Lorusso, Roberto; Al Awami, Fatima; Matteuci, Francesco; Parise, Orlando; Lozekoot, Pieter; Bonacchi, Massimo; Maessen, Jos G.; Johnson, Daniel M. and Gelsomino, Sandro (2018). Vascular complications following intra-aortic balloon pump implantation: an updated review. Perfusion, 33(2) pp. 96–104.

• Download Published Version (PDF / 579kB)

Dries, Eef; Santiago, Demetrio J; Gilbert, Guillaume; Lenaerts, Ilse; Vandenberk, Bert; Nagaraju, Chandan K; Johnson, Daniel M; Holemans, Patricia; Roderick, H Llewelyn; Macquaide, Niall; Claus, Piet and Sipido, Karin R (2018). Hyperactive ryanodine receptors in human heart failure and ischaemic cardiomyopathy reside outside of couplons. Cardiovascular Research, 114(11) pp. 1512–1524.

• Download Published Version (PDF / 2MB)

Fumagalli, Francesca Maria (2018). Preclinical Optimization of Treatment with Inhaled Argon to Improve Neurological Outcome and Survival After Cardiac Arrest. PhD thesis The Open University.

• Download Final Version (PDF / 4MB)

Gelsomino, Sandro; Bidar, Elham; Lorusso, Roberto; Johnson, Daniel M.; Maessen, Jos G. and Natour, Ehsan (2018). Open repair of type Ia endoleak in the aortic arch: three tailored approaches. Journal of Thoracic Disease, 10(11) pp. 6261–6265.

• Download Published Version (PDF / 1MB)

Gelsomino, Sandro; Johnson, Daniel M. and Lorusso, Roberto (2018). [Editorial] Intra-aortic balloon pump: is the tide turning? Critical Care, 22(1), article no. 345.

• Download Published Version (PDF / 433kB)

Gomes, Anna; Jainandunsing, Jayant S.; van Assen, Sander; van Geel, Peter Paul; Sinha, Bhanu; Gelsomino, Sandro; Johnson, Daniel M. and Natour, Ehsan (2018). A standardized approach to treat complex aortic valve endocarditis: a case series. Journal of Cardiothoracic Surgery, 13(1), article no. 32.

• Download Published Version (PDF / 4MB)

Johnson, Daniel M. and Antoons, Gudrun (2018). Arrhythmogenic Mechanisms in Heart Failure: Linking β-Adrenergic Stimulation, Stretch, and Calcium. Frontiers in Physiology, 9, article no. 1453.

• Download Published Version (PDF / 4MB)

Lorusso, Roberto; Vizzardi, Enrico; Johnson, Daniel M; Mariscalco, Giovanni; Sciatti, Edoardo; Maessen, Jos; Bidar, Elham and Gelsomino, Sandro (2018). Cardiac surgery in adult patients with remitted or active malignancies: a review of preoperative screening, surgical management and short- and long-term postoperative results. European Journal of Cardio-Thoracic Surgery, 54(1) pp. 10–18.

Masoud, Said (2018). The Ultrastructural and Abnormal Calcium Handling in Pulmonary Vein Sleeve Cells, Atrial and Ventricular Myocytes During Ageing. PhD thesis The Open University.

• Download Final Version (PDF / 15MB)

Nicol, Thomas Leslie (2018). The Role of ECSIT in Mitochondrial Dysfunction Mediated Cardiomyopathy. PhD thesis The Open University.

• Download Final Version (PDF / 9MB)

Rienks, Marieke; Carai, Paolo; van Teeffelen, Jurgen; Eskens, Bart; Verhesen, Wouter; Hemmeryckx, Bianca; Johnson, Daniel M.; van Leeuwen, Rick; Jones, Elizabeth A.; Heymans, Stephane and Papageorgiou, Anna-Pia (2018). SPARC preserves endothelial glycocalyx integrity, and protects against adverse cardiac inflammation and injury during viral myocarditis. Matrix Biology, 74 pp. 21–34.

• Download Published Version (PDF / 2MB)

Rietdorf, Katja; Coode, Emily; MacDonald, Fraser; Bister, Dirk and Bootman, Martin (2018). Broken Hearts in Juvenile Dementia: investigating cardiac myocytes in CLN3 disease. In: International Meeting of the European Calcium Society, 9-13 Sep 2018, Hamburg, Germany.

Smyrnias, Ioannis; Goodwin, Normann; Wachten, Dagmar; Skogestad, Jonas; Aronsen, Jan Magnus; Robinson, Emma L.; Demydenko, Kateryna; Segonds-Pichon, Anne; Oxley, David; Sadayappan, Sakthivel; Sipido, Karin; Bootman, Martin D. and Roderick, H. Llewelyn (2018). Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes. Journal of Molecular and Cellular Cardiology, 117 pp. 1–18.

• Download Accepted Manuscript (PDF / 4MB)

Torrini, Consuelo (2018). Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules. PhD thesis The Open University.

• Download Final Version (PDF / 83MB)

Hyde, Caroline A. C.; Berger, Philipp and Ballmer-Hofer, Kurt (2014). Finding New Partnerships: The Function of Individual Extracellular Receptor Domains in Angiogenic Signalling by VEGF Receptors. In: Feige, Jean-Jacques; Pagès, Gilles and Soncin, Fabrice eds. Molecular Mechanisms of Angiogenesis. Paris: Springer, pp. 47–75.

Hyde, Caroline A. C.; Giese, Alexandra; Stuttfeld, Edward; Abram Saliba, Johan; Villemagne, Denis; Schleier, Thomas; Binz, H. Kaspar and Ballmer-Hofer, Kurt (2012). Targeting Extracellular Domains D4 and D7 of Vascular Endothelial Growth Factor Receptor 2 Reveals Allosteric Receptor Regulatory Sites. Molecular and Cellular Biology, 32(19) pp. 3802–3813.

• Download Published Version (PDF / 2MB)