Currently browsing: Items authored or edited by Yao Xu https://orcid.org/0000-0002-5713-8030

Sato, Rin; Yamada, Yoshino; Kashihara, Wataru; Nishihara, Tatsuya; Tanabe, Kazuhito; Xu, Yao-Zhong and Suzuki, Tadashi (2024). Excited state properties of 5‐fluoro‐4‐thiouridine derivative^†. Photochemistry and Photobiology (Early Access).

Perry, Elliot D.; Chapman, Simon and Xu, Yao-Zhong (2023). SARS-CoV-2 Main Protease Inhibitors: Structure-Based Enhancement to Anti-Viral Pre-Clinical GC376 Encourages Further Development. Journal of Computational Biophysics and Chemistry, 22(4) pp. 383–399.

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Chapman, Simon; Ghesquiere, Pierre; Perry, Elliot; Taylor, Peter Geoffrey; Power, Nicholas P.; Sansom, Clare E. and Xu, Yao-Zhong (2021). Adenine Quadruplexes Show Surprising Stability: Potential Implications for SARS-CoV-2. Journal of Computational Biophysics and Chemistry, 20(7) pp. 675–685.

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Nonoshita, Daiki; Kashihara, Wataru; Tanabe, Kazuhito; Isozaki, Tasuku; Xu, Yao−Zhong and Suzuki, Tadashi (2021). Excited States of Thio-2′-deoxyuridine Bearing an Extended π-Conjugated System: 3′,5′-Di-O-acetyl-5-phenylethynyl-4-thio-2′-deoxyuridine. The Journal of Physical Chemistry A, 125(2) pp. 597–606.

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Ando, Saki; Isozaki, Tasuku; Xu, Yao-Zhong and Suzuki, Tadashi (2020). Simultaneous Two-Photon Absorption of the Thioguanosine Analogue 2′,3′,5′-Tri‑O‑acetyl-6,8-dithioguanosine with Its Potential Application to Photodynamic Therapy. The Journal of Physical Chemistry A, 124(35) pp. 7024–7030.

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Miyata, Shoma; Tanabe, Shunsuke; Isozaki, Tasuku; Xu, Yao-Zhong and Suzuki, Tadashi (2018). Characteristics of the Excited Triplet States of Thiolated Guanosine Derivatives and Singlet Oxygen Generation. Photochemical & Photobiological Sciences, 17(10) pp. 1469–1476.

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Miyata, Shoma; Yamada, Takeshi; Isozaki, Tasuku; Sugimura, Hideyuki; Xu, Yao-Zhong and Suzuki, Tadashi (2018). Absorption Characteristics and Quantum Yields of Singlet Oxygen Generation of Thioguanosine Derivatives. Photochemistry and Photobiology, 94(4) pp. 677–684.

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Miyata, Shoma; Hoshino, Mina; Isozaku, Tasuku; Yamada, Takeshi; Sugimura, Hideyuki; Xu, Yao-Zhong and Suzuki, Tadashi (2018). Acid Dissociation Equilibrium and Singlet Molecular Oxygen Quantum Yield of Acetylated 6,8–Dithioguanosine in Aqueous Buffer Solution. Journal of Physical Chemistry B, 122(11) pp. 2912–2921.

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Miyata, Shoma; Aoki, Ui; Tanabe, Shunsuke; Isozaki, Tasuku; Xu, Yao-Zhong. and Suzuki, Tadashi (2018). Formation of oxidative photoproduct of tri-acetyl-modified 6-thioguanosine by UVA irradiation. Photomedicine and photobiology, 39 pp. 15–18.

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Moore, Elaine Ann and Xu, Yao-Zhong (2017). The effect of S-substitution at the O6-guanine site on the structure and dynamics of a DNA oligomer containing a G:T mismatch. PLoS ONE, 12(9), article no. e0184801.

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Zhang, Xiao-Hui and Xu, Yao-Zhong (2016). NMR studies on 4-thio-5-furan-modified and 4-thio-5-thiophene-modified nucleosides. Magnetic Resonance in Chemistry, 54(11) pp. 887–892.

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Zhang, Xiaohui; Yan, Defeng; Ma, Kedong; He, Lingshuang; Gao, Ruiqi; Xu, Yaozhong and Li, Depeng (2016). The Synthesis of (E)-4-Thio-5-(2-Bromovinyl)Uridine/Deoxyuridine and Its Characterization and Cytotoxicity. Chinese Journal of Organic Chemistry, 36(12) pp. 2989–2996.

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Ge, Jiang; Feng, Luo; Yaozhong, Xu and Xiaohui, Zhang (2016). UVA Assisted 4-Thiothymidine for Cancer Treatment. Progress in Chemistry, 28(8) pp. 1224–1237.

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Zhang, Xiaohui; Li, Depeng; Qin, Jianzhong; Xu, Yaozhong and Ma, Kedong (2016). Synthesis of 4-thio-5-(2′′-thienyl)uridine and cytotoxicity activity against colon cancer cells in vitro. RSC Advances, 6(74) pp. 70099–70105.

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Brem, Reto; Zhang, Xiaohui; Xu, Yao-Zhong and Karran, Peter (2015). UVA photoactivation of DNA containing halogenated thiopyrimidines induces cytotoxic DNA lesions. Journal of Photochemistry and Photobiology B: Biology, 145(4) pp. 1–10.

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Narukulla, Raman and Xu, Yao-Zhong (2015). Nucleotides and oligonucleotides: mononucleotides. In: Allen, David; Tebby, John C. and Loakes, David eds. Organophosphorus Chemistry, Volume 44. Cambridge: The Royal Society of Chemistry, pp. 170–192.

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Trigiante, Guiseppe and Xu, Yao-Zhong (2015). 4-thiothymidine and its analogues as UVA-activated photosensitizers. In: Hugo, Adrian G. ed. Photodynamic Therapy: Fundamentals, Applications and Health Outcomes. Cancer Etiology, Diagnosis and Treatments. Hauppauge, NY: Nova SciencePublishers, pp. 193–206.

Zhang, Xiao-Hui; Yin, Hong-Yan; Trigiante, Joseph; Brem, Reto; Karran, Peter; Pitak, Mateusz B.; Coles, Simon J. and Xu, Yao-Zhong (2015). 5-iodo-4-thio-2′-deoxyuridine: synthesis, structure, and cytotoxic activity. Chemistry Letters, 44(2) pp. 147–149.

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Xu, Yao-Zhong and Narukulla, Raman (2014). Nucleotides and oligonucleotides: mononucleotides. In: Allen, David; Tebby, John C. and Loakes, David eds. Organophosphorus Chemistry, Volume 43. Cambridge: The Royal Society of Chemistry, pp. 117–145.

Pitman, Simone; Xu, Yao; Taylor, Peter and Turner, Nicholas (2014). Spotlight on medicinal chemistry education. Future Medicinal Chemistry, 6(8) pp. 865–869.

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Zhang, Xiaohui; Wang, Jian and Xu, Yao-Zhong (2013). Systematic assignment of NMR spectra of 5-substituted-4-thiopyrimidine nucleosides. Magnetic Resonance in Chemistry, 51(9) pp. 523–529.

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Gemenetzidis, Emilios; Shavorskaya, Oksana; Xu, Yao-Zhong and Trigiante, Giuseppe (2013). Topical 4-thiothymidine is a viable photosensitiser for the photodynamic therapy of skin malignancies. Journal of Dermatological Treatment, 24(3) pp. 209–214.

Yin, Hong-yan; Zhang, Xiao-hui and Xu, Yao-zhong (2011). Study on synthesis and fluorescence spectra of 5-bromor-4-thio-2′-deoxyuridine labeled with monobromobimanes fluorescein. Journal of Molecular Science, 27(6) pp. 397–401.

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Zhang, Xiaohui and Xu, Yao-Zhong (2011). NMR and UV studies of 4-Thio-2′-deoxyuridine and its derivatives. Molecules, 16(7) pp. 5655–5664.

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Pridgeon, S. W.; Heer, R.; Taylor, G. A.; Newell, D. R.; O'Toole, K.; Robinson, M.; Xu, Y-Z; Karran, P. and Boddy, A. V. (2011). Thiothymidine combined with UVA as a potential novel therapy for bladder cancer. British Journal of Cancer, 104(12) pp. 1869–1876.

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Reelfs, Olivier; Macpherson, Peter; Ren, Xiaolin; Xu, Yao-Zhong; Karran, Peter and Young, Antony R. (2011). Identification of potentially cytotoxic lesions induced by UVA photoactivation of DNA 4-thiothymidine in human cells. Nucleic Acids Research, 39(22) pp. 9620–9632.

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Ren, Xiaolin; Xu, Yao-Zhong and Karren, Peter (2010). Photo-oxidation of 6-thioguanine by UVA: the formation of addition products with low molecular weight thiol compounds. Photochemistry and Photobiology, 86(5) pp. 1038–1045.

Zhang, X. H.; Wang, A. L.; Li, D. P. and Xu, Y.-Z. (2010). UVA light-assisted anticancer drugs - study on 4-thiothymidine and its analogues. Progress in Chemistry, 22(5) pp. 784–795.

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Ren, Xiaolin; Li, Feng; Jeffs, Graham; Zhang, Xiaohong; Xu, Yao-Zhong and Karran, Peter (2010). Guanine sulphinate is a major stable product of photochemical oxidation of DNA 6-thioguanine by UVA irradiation. Nucleic Acids Research, 38(6) pp. 1832–1840.

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Harada, Yosuke; Okabe, Chie; Kobayashi, Takashi; Suzuki, Tadashi; Ichimura, Teijiro; Nishi, Nobuyuki and Xu, Yao-Zhong (2010). Ultrafast intersystem crossing of 4-Thiothymidine inaqueous solution. Journal of Physical Chemistry Letters, 1(2) pp. 480–484.

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Narukulla, Raman; Shuker, David E. G.; Ramesh, Vasudevan and Xu, Yao-Zhong (2008). Unambiguous structural elucidation of base-modified purine nucleosides using NMR. Magnetic Resonance in Chemistry, 46(1) pp. 1–8.

Montaneri, Beatriz; O'Donovan, Peter; Reelfs, Olivier; Perrett, Conal M; Zhang, Xiaohong; Xu, Yao-Zhong; Ren, Xiaolin; Macpherson, Peter; Frith, David and Karran, Peter (2007). Reactive oxygen-mediated damage to a human DNA replication and repair protein. EMBO Reports, 8(11) pp. 1074–1079.

Reelfs, Olivier; Xu, Yao-Zhong; Massey, Andrew; Karran, Peter and Storey, Alan (2007). Thiothymidine plus low-dose UVA kills hyperproliferativehuman skin cells independently of their human papilloma virus status. Molecular Cancer Therapeutics, 6 pp. 2487–2495.

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Harada, Y; Suzuki, T; Ichimura, T and Xu, YZ (2007). Triplet Formation of 4-Thiothymidine and Its Photosensitization to Oxygen Studied by Time-Resolved Thermal Lensing Technique. Journal of Physical Chemistry B, 111(19) pp. 5518–5524.

Zhang, Xiaohong; Jeffs, Graham; Ren, Xiaolin; O'Donovan, Peter; Montaner, Beatriz; Perrett, Conal M.; Karran, Peter and Xu, Yao-Zhong (2007). Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light. DNA Repair, 6(3) pp. 344–354.

O'Donovan, Peter; Perrett, Conal M.; Zhang, Xiaohong; Montaner, Beatriz; Xu, Yao-Zhong; Harwood, Catherine A.; McGregor, Jane M.; Walker, Susan L.; Hanaoka, Fumio and Karran, Peter (2005). Azathioprine and UVA Light generate mutagenic oxidative DNA damage. Science, 309(5742) pp. 1871–1874.

Narukulla, Raman; Shuker, David E.G. and Xu, Yao-Zhong (2005). Post-synthetic and site-specific modification of endocyclic nitrogen atoms of purines in DNA and its potential for biological and structural studies. Nucleic Acids Research, 33(6) pp. 1767–1778.

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Lari, Sibghat-Ullah; Xu, Yao-Zhong and Day, Rufus S. (2005). Evidence for three thymine DNA glycosylases in human cell extracts: substrate specific cities of thymine DNA glycosylase activities. Medical Science Monitor, 11(2) pp. 41–49.

Xu, Yao-Zhong; Zhang, Xiaohui; Wu, Hai-Chen; Massey, Andrew and Karran, Peter (2004). 4-Thio-5-bromo-2′-deoxyuridine: chemical synthesis and therapeutic potential of UVA-induced DNA damage. Bioorganic and Medicinal Chemistry Letters, 14(4) pp. 995–997.

Massey, Andrew; Xu, Yao-Zhong and Karran, Peter (2002). Ambiguous coding is required for the lethal interaction between methylated DNA bases and DNA mismatch repair. DNA Repair, 1(4) pp. 275–286.

Xu, Yao-Zhong (2002). Synthetic chemistry of base-modified DNA and their biological applications. In: Loakes, David ed. Modified Nulceoside, Synthesis and Applications. Kerala, India: Research Signpost, pp. 1–16.

Massey, Andrew; Xu, Yao-Zhong and Karran, Peter (2001). Photoactivation of DNA thiobases as a potential novel therapeutic option. Current Biology, 11(14) pp. 1142–1146.