Currently browsing: Items authored or edited by Jill Saffrey

Yeoman, Mark S.; Fidalgo, Sara; Hobby, India; Hafeez, Ali; Ranson, Rachel N.; Saffrey, M. Jill and Patel, Bhavik Anil (2024). Decreases in mucosally‐evoked tachykinin signaling pathways can explain age‐related reductions in murine colonic motility patterns. Neurogastroenterology & Motility (Early access).

• Download Published Version (PDF / 2MB)

Goodall, Emily F.; Leach, Vicki; Wang, Chunfang; Cooper-Knock, Johnathan; Heath, Paul R.; Baker, David; Drew, David R.; Saffrey, M. Jill; Simpson, Julie E.; Romero, Ignacio A. and Wharton, Stephen B. (2019). Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier. International Journal of Molecular Sciences, 20(12), article no. 3097.

• Download Published Version (PDF / 3MB)

Broad, John; Kung, Victor W. S.; Palmer, Alexandra; Elahi, Shezan; Karami, Azadeh; Darreh-Shori, Taher; Ahmed, Shafi; Thaha, Mohamed Adhnan; Carroll, Rebecca; Chin-Aleong, Joanne; Martin, Joanne E.; Saffrey, M. Jill; Knowles, Charles H. and Sanger, Gareth John (2019). Changes in neuromuscular structure and functions of human colon during ageing are region-dependent. Gut, 68(7) pp. 1210–1223.

• Download Published Version (PDF / 2MB)

Johnson, Michelle L.; Saffrey, M. Jill and Taylor, Victoria Jane (2019). Gastrointestinal capacity, gut hormones and appetite change during rat pregnancy and lactation. Reproduction, 157(5) pp. 431–443.

• Download Accepted Manuscript (PDF / 244kB)

Gamage, Prasanna P. K. M.; Patel, Bhavik A.; Yeoman, Mark S.; Ranson, Rachel N. and Saffrey, M. Jill (2018). Interstitial cell network volume is reduced in the terminal bowel of ageing mice. Journal of Cellular and Molecular Medicine, 22(10) pp. 5160–5164.

• Download Published Version (PDF / 448kB)

Fidalgo, S.; Patel, B. A.; Ranson, R. N.; Saffrey, M. J. and Yeoman, M. S. (2018). Changes in murine anorectum signaling across the life course. Neurogastroenterology & Motility, 30(10), article no. e13426.

• Download Published Version (PDF / 1MB)

Goodall, Emily F.; Wang, Chunfang; Simpson, Julie E.; Baker, David J.; Drew, David R.; Heath, Paul R.; Saffrey, M. Jill; Romero, Ignacio A. and Wharton, Stephen B. (2018). Age-associated changes in the blood brain barrier: Comparative studies in human and mouse. Neuropathology and Applied Neurobiology, 44(3) pp. 328–340.

• Download Published Version (PDF / 925kB)

Johnson, Michelle L.; Saffrey, M. Jill and Taylor, Victoria J. (2017). Glucagon-like peptide-1 (GLP-1) increases in plasma and colon tissue prior to estrus and circulating levels change with increasing age in reproductively competent Wistar rats. Peptides, 90 pp. 55–62.

• Download Accepted Manuscript (PDF / 297kB)

Johnson, Michelle L.; Saffrey, M. Jill and Taylor, Victoria J. (2016). Plasma Ghrelin Concentrations Were Altered with Oestrous Cycle Stage and Increasing Age in Reproductively Competent Wistar Females. PLoS ONE, 11(11), article no. e0166229.

• Download Published Version (PDF / 842kB)

Johnson, Michelle; Saffrey, M. J. and Taylor, V. J. (2016). Hyperphagia of pregnancy and lactation is associated with changes in appetite-regulating hormones and gastrointestinal modifications in Wistar rats. In: Annual Meetings of the Endocrine Society of Australia and Society for Reproductive Biology and Australia and New Zealand Bone and Mineral Society 2016, 21-24 Aug 2016, Gold Coast, Australia.

Johnson, Michelle L.; Saffrey, M. Jill and Taylor, Victoria J. (2016). Pup sex and body mass of rats raised in different lactation litter sizes affect ghrelin and peptide-YY concentrations. In: Reproduction Abstracts, Bioscientifica, 3, article no. P043.

Johnson, Michelle L.; Saffrey, Jill and Taylor, Vicky J. (2015). Hyperphagia of pregnancy and lactation is associated with changes in appetite-regulating hormones and gastrointestinal modifications in Wistar rats. In: Reproduction Abstracts, Bioscientifica, 2, article no. 0002.

Ranson, Richard N. and Saffrey, M. Jill (2015). Neurogenic mechanisms in bladder and bowel ageing. Biogerontology, 16(2) pp. 265–284.

• Download Published Version (PDF / 638kB)

Saffrey, M. Jill (2014). Aging of the mammalian gastrointestinal tract: a complex organ system. AGE - The Journal of the American Aging Association, 36(3) pp. 1019–1032.

• Download Proof (PDF / 480kB)

Johnson, Michelle L.; Saffrey, M. Jill and Taylor, Vicky J. (2014). Sex differences in gut satiety hormones peptide-YY and glucagon-like peptide-1 in pups raised in larger lactation litter sizes. In: Society for Reproduction and Fertility Annual Conference 2014, 1-2 Sep 2014, Edinburgh.

Johnson, Michelle L.; Saffrey, M. Jill and Taylor, Vicky J. (2014). Lactation litter size differentially affects satiety hormone concentrations and gut adaptations in Wistar rat dams. In: World Congress of Reproductive Biology 2014, 2-4 Sep 2014, Edinburgh.

Coulombe, Josée; Gamage, Prasanna; Gray, Madison T.; Zhang, Mei; Tang, Matthew Y.; Woulfe, John; Saffrey, M. Jill and Gray, Douglas A. (2014). Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system. Frontiers in Aging Neuroscience, 6, article no. 129.

• Download Published Version (PDF / 3MB)

Patel, Bhavik Anil; Patel, Nikkita; Fidalgo, Sara; Wang, Chunfang; Ranson, Richard N.; Saffrey, M. Jill and Yeoman, Mark S. (2014). Impaired colonic motility and reduction in tachykinin signalling in aged mouse. Experimental Gerontology, 53 pp. 24–30.

• Download Accepted Manuscript (PDF / 499kB)

Johnson, M. L.; Taylor, V. J.; Ranson, R. N. and Saffrey, M. J. (2014). Changes in appetite hormone-producing enteroendocrine cells in the C57BL/6 mouse stomach during ageing. In: Conference abstracts of British Society for Research on Ageing 64th Annual Scientific meeting. 'Exercise, Activity and Ageing Mechanisms', article no. 32.

Tsang, Hayley; Zhang, Meng; Black, Gary W.; Saffrey, M. Jill and Ranson, Richard N. (2014). Changes in immunoreactive terminals containing serotonin, substance P, vesicular glutamate transporter 2 and corticotropin-releasing factor in the lumbosacral spinal cord of aged C56BL/6J male mice. In: Conference proceedings of British Society for Research on Ageing 64th Annual Meeting 'Exercise, Activity and Ageing Mechanisms', article no. 39.

Saffrey, M. Jill (2013). Cellular changes in the enteric nervous system during ageing. Developmental Biology, 382(1) pp. 344–355.

Wang, C.; Houghton, M. J.; Gamage, P. P.K.M; Collins, H. E.; Patel, B. A.; Yeoman, M. S.; Ranson, R. N. and Saffrey, M. J. (2013). Changes in the innervation of the mouse internal anal sphincter during aging. Neurogastroenterology and Motility, 25(7) e469-e477.

Johnson, Michelle; Saffrey, Jill and Taylor, Victoria (2013). Gastrointestinal changes during lactation are further altered by litter size in Wistar rats. In: The Society for Reproduction and Fertility Annual Meeting 2013, 11-13 Jul 2013, Fitzwilliam College, University of Cambridge.

Johnson, Michelle; Saffrey, Jill and Taylor, Victoria (2013). Increased glucagon-like peptide-1 concentration in rat descending colon during proestrus is associated with decreased food intake at estrus. In: SSR's 46th Annual Meeting Reproductive Health: Nano to Global, 22-26 Jul 2013, Montréal, Québec, Canada, pp. 150–151.

Johnson, Michelle; Saffrey, Jill and Taylor, Victoria (2013). Changes in appetite hormones and gut tissue architecture during the rat reproductive cycle, pregnancy and lactation. In: Programming obesity: central and peripheral contributors, 14-16 Apr 2013, Cambridge, UK.

Gamage, P. P. K. M.; Ranson, R. N.; Patel, B. A.; Yeoman, M. S. and Saffrey, M. J. (2013). Myenteric neuron numbers are maintained in aging mouse distal colon. Neurogastroenterology and Motility, 25(7) e495-e505.

Saffrey, M. Jill; Gamage, Prasanna P. K. M.; Davies, Heather A.; Colyer, Frances M.; Patel, Bhavik A.; Yeoman, Mark S. and Ranson, Richard N. (2013). Degenerative changes in neurons and interstitial cells of cajal in mouse internal anal sphincter during aging. In: American Aging Association 42nd Annual Meeting: Aging: Prevention, Reversal, and Slowing, 31 May - 3 Jun 2013, Baltimore, MD, USA.

Tsang, H.; Zhang, M.; Black, G.; Saffrey, M. J. and Ranson, R. N (2013). Age-related changes to lumbosacral spinal cord motoneurons that modulate bladder and bowel functions in male C57BL/6 mice. In: British Society for Research on Ageing Annual Scientific Meeting, 2-4 Sep 2013, Institute of Food Research, University of East Anglia, Norwich, p. 25.

• Download Published Version (PDF / 735kB)

Saffrey, M.Jill; Gamage, Prasanna; Davies, Heather; Colyer, Frances; Yeoman, Mark and Ranson, Richard N. (2013). Ultrastructural analysis of changes in neurons of the mouse internal anal sphincter during ageing. In: British Society for Research on Ageing Annual Scientific Meeting, 2-4 Sep 2013, Institute of Food Research, University of East Anglia, Norwich, p. 32.

• Download Published Version (PDF / 735kB)

Wang, C.; Saffrey, M. J. and Romero, I. A. (2013). Age-related changes in blood-brain barrier integrity in C57BL/6J mice. In: British Society for Research on Ageing Annual Scientific Meeting, 2-4 Sep 2013, Institute of Food Research, University of East Anglia, Norwich, p. 36.

• Download Published Version (PDF / 735kB)

Jurk, Diana; Wang, Chunfang; Miwa, Satomi; Maddick, Mandy; Korolchuk, Viktor; Tsolou, Avgi; Gonos, Efstathios S.; Thrasivoulou, Christopher; Saffrey, M. Jill; Cameron, Kerry and von Zglinicki, Thomas (2012). Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell, 11(6) pp. 996–1004.

• Download Published Version (PDF / 1MB)

Johnson, Michelle; Saffrey, Jill and Taylor, Victoria (2012). Do circulating and tissue concentrations of ghrelin and peptide-YY (PYY) change during the oestrous cycle in Wistar Rats? In: Society for Reproduction and Fertility Annual Conference 2012, 9-11 Jul 2012, Edinburgh.

Hoyle, C. H. V. and Saffrey, M. J. (2012). Effects of aging on cholinergic neuromuscular transmission in isolated small intestine of ad libitum fed and calorically-restricted rats. Neurogastroenterology & Motility, 24(6) pp. 586–592.

Korsak, Kris; Silva, Ayona T. and Saffrey, M. Jill (2012). Differing effects of NT-3 and GDNF on dissociated enteric ganglion cells exposed to hydrogen peroxide in vitro. Neuroscience Letters, 517(2) pp. 102–106.

• Download Accepted Manuscript (PDF / 262kB)

Korsak, Kris; Dolatshad, Nazanin F.; Silva, Ayona T. and Saffrey, M. Jill (2012). Ageing of enteric neurons: oxidative stress, neurotrophic factors and antioxidant enzymes. Chemistry Central Journal, 6(80)

• Download Published Version (PDF / 2MB)

Patel, B.; Parmar, L.; Fidalgo, S.; Wang, C.; Ranson, R.; Saffrey, J. and Yeoman, M. (2012). Effect of age on mucosal serotonin signalling and circular muscle contractions in the murine rectum. In: Neurogastroenterology & Motility, 24(S2) p. 84.

Patel, B.; Fidalgo, S.; Ranson, R.; Saffrey, J. and Yeoman, M. (2012). Age-related change in cholinergic and nitrergic signaling in the mouse rectum. In: Neurogastroenterology & Motility, 24(S2) p. 120.

Saffrey, M. J.; Wang, C.; Gamage, P.; Davies, H.; Colyer, F.; Houghton, M.; Patel, B.; Yeoman, M. and Ranson, R. (2012). Analysis of changes in the cells of the mouse internal anal sphincter during aging. In: Neurogastroenterology & Motility, 24(S2) p. 125.

Patel, B.; Yeoman, M.; Fidalgo, S.; Dhulia, P.; Girdlestone, I.; Ranson, R. and Saffrey, J. (2012). Decrease in serotonin-induced tachykinin signaling can account for age-related reductions in the amplitude and the frequency of Colonic Migrating Motor Complexes (CMMCS) in the murine distal colon. In: Neurogastroenterology & Motility, 24(S2) p. 128.

Patel, B.; Patel, N.; Fidalgo, S.; Ranson, R.; Saffrey, J. and Yeoman, M. (2012). Age-related changes in colonic motility, faecal output and the properties of faecal pellets in the mouse. In: Neurogastroenterology & Motility, 24(S2) p. 129.

Patel, B.; Fidalgo, S.; Ranson, R.; Saffrey, J. and Yeoman, M. (2012). Age-related changes in nitrergic and purinergic signaling in the mouse internal anal sphincter. In: Neurogastroenterology & Motility, 24(S2) p. 125.

Saffrey, M. J.; Gamage, P. P. K. M.; Davies, H. A.; Colyer, F. M.; Houghton, M.; Wang, C. and Ranson, R. N. (2012). Analysis of changes in the enteric nervous system of the mouse during ageing. In: 8th FENS Forum of Neuroscience, 14-18 Jul 2012, Barcelona, Spain.

Saffrey, M.J. (2012). Changes in the enteric nervous system and surrounding cells during ageing. In: 3rd International Symposium on Development of the Enteric Nervous System: Cells Signals, and Genes, 25-28 Mar 2012, Hong Kong, p. 62.

• Download Published Version (PDF / 545kB)

Saffrey, M. Jill (2011). Aging of the mammalian gastrointestinal system. In: 40th Annual American Aging Association meeting:'Mechanisms of Aging: Emerging Concepts', 4-6 Jun 2011, Raleigh, North Carolina, USA, pp. 44–45.

Froud, Kristina E.; Wardhaugh, Tina; Banks, Duncan; Saffrey, M. Jill and Stewart, Michael G. (2010). Colostrinin™ alleviates amyloid-β induced toxicity in rat primary hippocampal cultures. Journal of Alzheimer's Disease, 20(2) pp. 423–426.

• Download Accepted Manuscript (PDF / 228kB)

Saffrey, M. J. (2009). Culture models of enteric neurones and glia: potential use in intestinal tissue engineering. In: Tissue Engineering: A New Dimension to Animal Replacement, 1-2 Apr 2009, London.

• Request a copy from the author This file is not available for public download

Saffrey, Jill (2009). Enteric nervous system: Neurotrophic factors. In: Squire, Larry R. ed. Encyclopedia of Neuroscience, Volume 3. Oxford, UK: Academic Press, pp. 1097–1102.

Silva, Ayona Therese; Wardhaugh, Tina; Dolatshad, Nazanin Fatima; Jones, Sarahlouise and Saffrey, Margaret Jill (2008). Neural progenitors from isolated postnatal rat myenteric ganglia: expansion as neurospheres and differentiation in vitro. Brain Research, 1218 pp. 47–53.

• Download Accepted Manuscript (PDF / 442kB)

Latta, Elizabeth; Saffrey, Jill and Golding, Jon (2008). Midline1 and the development of the cranial peripheral nervous system. In: Joint meeting of the British and Spanish Developmental Biology Societies, 24-27 Sep 2008, Seville, Spain.

• Download Published Version (PDF / 1MB)

Froud, K.; Saffrey, M. J.; Stewart, M. G.; Banks, D. and Wardhaugh, T. (2008). The protective effect of colostrinin CLN(TM) against beta-amyloid and an oxidative stress inducer, menadione, in primary hippocampal cultures. In: FENS Forum 2008, 12-16 Jul 2008, Geneva.

• Published Version (PDF) This file is not available for public download

Dolatshad, N. F. and Saffrey, M. J. (2007). Differential expression of glial cell line-derived neurotrophic factor family receptor alpha-2 isoforms in rat urinary bladder and intestine. Neuroscience Letters, 415(3) pp. 215–218.

Froud, K. E.; Wardhaugh, T.; Stewart, M. G.; Banks, D. and Saffrey, M. J. (2006). Investigation of the mechanism of action of Colostrinin(TM) on neurons in culture. In: FENS Forum Abstracts, FENS, 3(A130.15).

Thrasivoulou, C.; Soubeyre, V.; Ridha, H.; Giuliani, D.; Giaroni, C.; Michael, G.J.; Saffrey, M.J. and Cowen, T. (2006). Reactive oxygen species, dietary restriction and neurotrophic factors in age-related loss of myenteric neurons. Aging Cell, 5(3) pp. 247–257.

Wright, K.E.; Liniker, E; MacRobert, A.J.; Brown, R.A.; Saffrey, M.J. and Phillips, J.B. (2006). Investigating the effect of photodynamic therapy on nerves using tissue engineered culture models. In: Tissue & Cell Engineering Society 2006, 3-4 Jul 2006, Sheffield, UK.

• Download Accepted Manuscript (PDF / 197kB)

Wright, K. E.; Liniker, E; MacRobert, A. J.; Saffrey, M. J.; Brown, R. A, and Phillips, J. B. (2006). Use of a tissue engineered model to investigate the effects of photodynamic therapy on peripheral nerves. In: European Chapter Meeting 2006, 8-11 Oct 2006, Rotterdam, p. 193.

Xeniou, Ourania; Romero, I.A. and Saffrey, M.J. (2005). Role of neurotrophic factors (NTF) and extracellular matrix components (ECM) on VIP expression in the rat enteric nervous system (ENS). In: Physiological Society Meeting, King's College London, Dec 2004, London, UK.

Saffrey, Jill (2005). Selective neuronal loss in the ageing enteric nervous system: causes and effects. In: British Neuroscience Association Abstracts, British Neuroscience Association, 18 p. 121.

Saffrey, M. Jill (2004). Ageing of the enteric nervous system. Mechanisms of Ageing and Development, 125(12) pp. 899–906.

Saffrey, M.J. (2004). Aging of the nervous system. In: Aspinall, Richard ed. Aging of the organs and systems. Biology of aging and its modulation (3). Kluwer Academic Publishers, pp. 243–270.

Korsak, K. K. and Saffrey, M. J. (2004). Protective effects of neurotrophic factors in the ENS in vitro. In: Society for Neuroscience, 39(11).

Xeniou, Ourania; Romero, Ignacio A and Saffrey, Jill (2003). Effects of neurotrophic factors on neurochemical differentiation of postnatal rat myenteric plexus ganglion cells in vitro. In: British Neuroscience Association Abstracts, British Neuroscience Association, 17 p. 48.

Xeniou, O.; Romero, I. and Saffrey, M. J. (2003). The role of neurotrophic factors and extracellular matrix components in postnatal myenteric neuronal differentiation. In: Neurogastroenterology and Motility, Blackwell, 15(2) p. 201.

Dolatshad,, Nazanin F.; Silva, Ayona T. and Saffrey, M. Jill (2002). Identification of GFR alpha-2 isoforms in myenteric plexus of postnatal and adult rat intestine. Molecular Brain Research, 107(1) pp. 32–38.

Hoyle, C. H. V.; Cowen, T. and Saffrey, M. J. (2002). Effects of age and diet on cholinergic neurotransmission in rat ileum. In: Society for Neuroscience 32nd Annual Meeting, 2-7 Nov 2002, Orlando, Florida.

Silva, A. T.; Dolatshad, N. F.; Soubeyre, V.; Hoyle, C. H.V.; Cowen, T. and Saffrey, M. J. (2001). Expression of the GDNF and its receptors in the ageing gut. In: Society for Neuroscience 31st Annual Meeting, 10-15 Nov 2001, San Diego, California.

Soubeyre, V.; Thrasivoulou, C.; Ridha, H.; Hoyle, C. H. V.; Saffrey, M. J. and Cowen, T. (2001). Free radical induced cell death in ageing rat enteric neurons: role of diet and neurotrophic factors. In: Society for Neuroscience 31st Annual Meeting, 10-15 Nov 2001, San Diego, California.