Currently browsing: Items authored or edited by David Male https://orcid.org/0000-0002-1242-3137

Rahatekar Singh, Nandita; Gromnicova, Radka; Brachner, Andreas; Kraev, Igor; Romero, Ignacio A; Neuhaus, Winfried and Male, David (2023). A hydrogel model of the human blood-brain barrier using differentiated stem cells. PLOS ONE, 18(4), article no. e0283954.

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Male, David and Gromnicova, Radka (2022). Nanocarriers for Delivery of Oligonucleotides to the CNS. International Journal of Molecular Sciences, 23(2), article no. 760.

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Roig-Carles, David; Willms, Eduard; Fontijn, Ruud D.; Martinez-Pacheco, Sarai; Mäger, Imre; de Vries, Helga E.; Hirst, Mark; Sharrack, Basil; Male, David K.; Hawkes, Cheryl A. and Romero, Ignacio A. (2021). Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation. Pharmaceutics, 13(9), article no. 1525.

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Frias Anaya, Eduardo; Gromnicova, Radka; Kraev, Igor; Rogachevsky, Vadim; Male, David; Crea, Francesco; Hawkes, Cheryl and Romero, Ignacio A. (2021). Age-related ultrastructural neurovascular changes in the female mouse cortex and hippocampus. Neurobiology of Aging, 101 pp. 273–284.

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Fatima, Nayab; Akcan, Ugur; Kaya, Mehmet; Gromnicova, Radka; Loughlin, Jane; Sharrack, Basil and Male, David (2021). Tissue distribution and cellular localization of gold nanocarriers with bound oligonucleotides. Nanomedicine, 16(9) pp. 709–720.

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Mcquaid, Conor; Halsey, Andrea; Dubois, Maeva; Romero, Ignacio A and Male, David (2021). Comparison of polypeptides that bind the transferrin receptor for targeting gold nanocarriers. PLoS ONE, 16(6), article no. e0252341.

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Kang, Ning; Eccleston, Mark; Clermont, Pier-Luc; Latarani, Maryam; Male, David Kingsley; Wang, Yuzhuo and Crea, Francesco (2020). EZH2 inhibition: a promising strategy to prevent cancer immune editing. Epigenomics, 12(16)

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Male, David; Peebles, R Stokes and Male, Victoria (2020). Immunology 9th edition. London: Elsevier.

Fatima, Nayab; Gromnicova, Radka; Loughlin, Jane; Sharrack, Basil and Male, David (2020). Gold nanocarriers for transport of oligonucleotides across brain endothelial cells. PLOS ONE, 15(9), article no. e0236611.

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Aparicio-Blanco, Juan; Romero, Ignacio A.; Male, David K.; Slowing, Karia; Garcia-Garcia, Luis and Torres-Suarez, Ana (2019). Cannabidiol Enhances the Passage of Lipid Nanocapsules across the Blood–Brain Barrier Both in Vitro and in Vivo. Molecular Pharmaceutics, 16(5) pp. 1999–2010.

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Silva-Abreu, Marcelle; Calpena, Ana Cristina; Benito, Pol Andres; Romero, Ignacio A.; Roig-Carles, David; Gromnicova, Radka; Espina, Marta; Ferrer, Isidre; Garcia, Maria Luisa and Male, David (2018). PPARγ agonist-loaded PLGA -PEG nanocarriers as a potential treatment for Alzheimer’s disease: in vitro and in vivo studies. International Journal of Nanomedicine, 13 pp. 5577–5590.

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Silva de Abreu, Marcelle; Calpena, Ana C.; Espina, Marta; Garcia, Maria Luisa; Romero, Ignacio A. and Male, David (2017). Toxicity and internalization of polymeric nanoparticles in brain endothelial cells. In: Fluids and Barriers of the CNS, BioMed Central, 14(Supp2) p. 19.

Cerutti, Camilla; Edwards, Laura J.; de Vries, Helga E.; Sharrack, Basil; Male, David K. and Romero, Ignacio A. (2017). MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium. Scientific Reports, 7 p. 45284.

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Gromnicova, Radka; Kaya, Mehmet; Romero, Ignacio A.; Williams, Phil; Satchell, Simon; Sharrack, Basil and Male, David (2016). Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues. PLoS ONE, 11(8), article no. e0161610.

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Gromnicova, Radka; Yilmaz, Canan Ugur; Orhan, Nurcan; Kaya, Mehmet; Davies, Heather; Williams, Phil; Romero, Ignacio A.; Sharrack, Basil and Male, David (2016). Localisation and mobility of glucose-coated gold nanoparticles within the brain. Nanomedicine, 11(6) pp. 617–625.

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Reddy, P; Gromnicova, Radka; Davies, Heather; Phillips, James; Romero, Ignacio A and Male, David (2016). A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions. F1000Research, 4, article no. 1279.

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Male, David; Gromnicova, Radka and Mcquaid, Conor (2016). Gold nanoparticles for imaging and drug transport to the CNS. In: Al-Jamal, Khuloud ed. Nanotechnology and the Brain. International Review of Neurobiology (130). London: Elsevier, pp. 155–189.

Wu, Dongsheng; Cerutti, Camilla; Lopez-Ramirez, Alejandro; Pryce, Gareth; King-Robson, Josh; Simpson, Julie E.; van der Pol, Susanne M. A.; Hirst, Mark C.; de Vries, Helga E.; Sharrack, Basil; Baker, David; Male, David K.; Michael, Gregory J. and Romero, Ignacio A (2015). Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. Journal of Cerebral Blood Flow & Metabolism, 35(3) pp. 412–23.

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Lopez-Ramirez, Miguel Alejandro; Wu, Dongsheng; Pryce, Gareth; Simpson, Julie E.; Reijerkerk, Arie; King-Robson, Josh; Kay, Oliver; de Vries, Helga E.; Hirst, Mark C.; Sharrack, Basil; Baker, David; Male, David Kingsley; Michael, Gregory J. and Romero, Ignacio Andres (2014). MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. FASEB Journal, 28(6) pp. 2551–2565.

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Gromnicova, Radka; Davies, Heather A.; Sreekanthreddy, Pedagannganagari; Romero, Ignacio A.; Lund, Torben; Roitt, Ivan M.; Phillips, James B. and Male, David K. (2013). Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro. PLoS ONE, 8(12), article no. e81043.

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Lopez-Ramirez, Miguel Alejandro; Male, David Kingsley; Wang, Chunfang; Sharrack, Basil; Wu, Dongsheng and Romero, Ignacio Andres (2013). Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3. Fluids and Barriers of the CNS, 10(1), article no. 27.

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Gromnicova, Radka; Romero, Ignacio A and Male, David (2012). Transcriptional control of the multi-drug transporter ABCB1 by transcription factor Sp3 in different human tissues. PLoS ONE, 7(10), article no. e48189.

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Male, David; Brostoff, Jonathan; Roth, David and Roitt, Ivan eds. (2012). Immunology (8th ed.). New York: Elsevier.

Lopez-Ramirez, Alejandro; Fischer, Roman; Torres-Badillo, Claudia C.; Davies, Heather A.; Logan, Karen; Pfizenmaier, Klaus; Male, David K.; Sharrack, Basil and Romero, Ignacio A. (2012). Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells. Journal of Immunology, 189(6) pp. 3130–3139.

Tai, L. M.; Holloway, K. A.; Male, D. K.; Loughlin, A. J. and Romero, I. A (2010). Amyloid-β-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation. Journal of Cellular and Molecular Medicine, 14(5) pp. 1101–1112.

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Tai, Leon M.; Reddy, P. Sreekanth; Lopez-Ramirez, M. Alejandro; Davies, Heather A.; Male, A. David K.; Loughlin, A. Jane and Romero, Ignacio A. (2009). Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123. Brain Research, 1292 pp. 14–24.

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Tai, Leon M.; Loughlin, A. Jane; Male, David K. and Romero, Ignacio A. (2009). P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-β. Journal of Cerebral Blood Flow and Metabolism, 29(6) pp. 1079–1083.

Sade, Hadassah; Holloway, Karen; Romero, Ignacio A. and Male, David (2009). Transcriptional control of occludin expression in vascular endothelia: regulation by Sp3 and YY1. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1789(3) pp. 175–184.

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Subileau, Eve A; Rezaie, Payam; Davies, Heather; Colyer, Frances; Greenwood, John; Male, David and Romero, Ignacio A (2009). Expression of chemokines and their receptors by human brain endothelium: Implications for multiple sclerosis. Journal of Neuropathology and Experimental Neurology, 68(3) pp. 227–240.

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Male, David K. (2009). Expression and induction of p-glycoprotein-1 on cultured human brain endothelium. Journal of Cerebral Blood Flow and Metabolism, 29(11) pp. 1760–1763.

Maru, Seema V.; Holloway, Karen A.; Flynn, Geraldine; Lancashire, Christine L.; Loughlin, A. Jane; Male, David K. and Romero, Ignacio A. (2008). Chemokine production and chemokine receptor expression by human glioma cells: Role of CXCL10 in tumour cell proliferation. Journal of Neuroimmunology, 199(1-2) pp. 35–45.

Holloway, Karen; Sade, Hadassah; Romero, Ignacio A. and Male, David (2007). Action of transcription factors in the control of transferrin receptor expression in human brain endothelium. Journal of Molecular Biology, 365(5) pp. 1271–1284.

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Mordelet, Elodie; Davies, Heather A.; Hillyer, Philippa; Romero, Ignacio A. and Male, David (2007). Chemokine transport across human vascular endothelial cells. Endothelium - Journal of Endothelial Cell Research, 14(1) pp. 7–15.

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Male, David ed. (2006). Immunology. 7th edition. UK: Elsevier.

Weksler, B.B.; Subileau, E.A.; Perriere, N.; Charneau, P.; Holloway, K.; Leveque, M.; Tricoire-Leignel, H.; Nicotra, A.; Bourdolos, S.; Tourowski, P.; Male, D.K.; Roux, F.; Greenwood, J.; Romero, I.A. and Couraud, P.O. (2005). Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB Journal, 19(13) pp. 1872–1874.

Hillyer, Phillipa and Male, David (2005). Expression of chemokines on the surface of different human endothelia. Immunology and Cell Biology, 83(4) pp. 375–382.

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Rezaie, Payam; Dean, Andrew; Male, David and Ulfig, Norbert (2005). Microglia in the cerebral wall of the human telencephalon at second trimester. Cerebral Cortex, 15(7) pp. 938–949.

Rezaie, Payam; Corbisiero, Vanessa and Male, David (2005). Transient expression of MIDC-8 in the normal mouse brain. Neuroscience Letters, 377(3) pp. 189–194.

Rezaie, P.; Male, D.K. and Ulfig, N. (2004). Microglial progenitors in the human forebrain during the second trimester [poster presentation]. In: 15th Biennial Meeting of the International Society for Developmental Neuroscience, 4-7 Aug 2004, Edinburgh, UK.

Hillyer, P.; Mordelet, E.; Flynn, G. and Male, D. (2003). Chemokines, chemokine receptors and adhesion molecules on different human endothelia: discriminating the tissue-specific functions that affect leucocyte migration. Clinical and Experimental Immunology, 134(3) pp. 431–441.

Male, David (2003). Immunology: an illustrated outline. 4th edition. London, UK: Elsevier.

Flynn, Geraldine; Maru, Seema; Loughlin, Jane; Romero, Ignacio A. and Male, David (2003). Regulation of chemokine receptor expression in human microglia and astrocytes. Journal of Neuroimmunology, 136(1-2) pp. 84–93.

Rezaie, Payam and Male, David (2003). Microglia in fetal and adult human brain can be distinguished from other mononuclear phagocytes through their lack of CD163 expression. Neuroembryology, 2(3) pp. 130–133.

Rezaie, Payam; Ulfig, Norbert and Male, David (2003). Distribution and morphology of GFAP-positive astrocytes in the human fetal brain at second trimester. Neuroembryology and Aging, 2(2) pp. 50–63.

Corbisiero, V.; Hagger, G.; Topps, S.; Kohsaka, S.; Imai, Y.; Male, D. and Rezaie, P. (2003). Colonization of the developing mouse brain by microglial progenitors [poster presentation]. In: Third International Symposium on Normal and Abnormal Development of the Human Fetal Brain, 13-15 Jun 2003, Zagreb, Croatia.

Jeetle, J.K.; Hagger, G.N.; Topps, S.S.; Male, D.K. and Rezaie, P. (2002). Microglial colonization of the developing mouse brain: the effects of CD11b deletion [poster presentation]. Neuropathology and Applied Neurobiology, 28 p. 164.

Rezaie, P.; Trillo-Pazos, G.; Greenwood, J.; Everall, I.P. and Male, D.K. (2002). Motility and ramification of human fetal microglia in culture: an investigation using time-lapse video microscopy and image analysis. Experimental Cell Research, 274(1) pp. 68–82.

Rezaie, Payam and Male, David (2002). Differentiation, ramification and distribution of Microglia within the central nervous system examined. Neuroembryology and Aging, 1(1) pp. 29–43.

Rezaie, Payam and Male, David (2002). Mesoglia & microglia: a historical review of the concept of mononuclear phagocytes within the central nervous system. Journal of the History of the Neurosciences, 11 pp. 325–374.

Rezaie, Payam; Trillo-Pazos, G.; Everall, I.P. and Male, David (2002). Expression of beta-chemokines and chemokine receptors in human fetal astrocyte and microglial co-cultures: potential role of chemokines in the developing CNS. Glia, 37(1) pp. 64–75.

Modo, Michael; Rezaie, Payam; Heuschling, Paul; Patel, Sara; Male, David K. and Hodges, Helen (2002). Transplantation of neural stem cells in a rat model of stroke: assessment of short-term graft survival and acute host immunological response. Brain Research, 958(1) pp. 70–82.

Jeetle, J.; Hagger, G.N.; Topps, S.; Male, David and Rezaie, Payam (2002). Microglia in the CD11b knockout mouse [poster presentation]. In: Second International Symposium on Normal and Abnormal Development of the Human Fetal Brain, 24-25 May 2002, Institute of Anatomy, University of Rostock, Germany.

Male, David and Rezaie, Payam (2001). Colonisation of the human central nervous system by microglia: the roles of chemokines and vascular adhesion molecules. Progress In Brain Research, 132 pp. 81–93.