Currently browsing: Items authored or edited by Christopher Heath https://orcid.org/0000-0003-3485-7128

Lopez-Cruz, Laura; Phillips, Benjamin U; Hailwood, Jon M; Saksida, Lisa M; Heath, Christopher and Bussey, Timothy J (2024). Refining the study of decision-making in animals: differential effects of d-amphetamine and haloperidol in a novel touchscreen-automated Rearing-Effort Discounting (RED) task and the Fixed-Ratio Effort Discounting (FRED) task. Neuropsychopharmacology, 49 pp. 422–432.

• Download Published Version (PDF / 2MB)

Cho, So Yeon; Kim, Eun Woo; Park, Soo Jin; Phillips, Benjamin U.; Jeong, Jihyeon; Kim, Hyunjeong; Heath, Christopher J.; Kim, Daehwan; Jang, Yurim; López-Cruz, Laura; Saksida, Lisa M.; Bussey, Timothy J.; Lee, Do Yup and Kim, Eosu (2024). Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer’s model mice. Translational Psychiatry, 14, article no. 34.

• Download Published Version (PDF / 3MB)

Foerster, Sarah; Floriddia, Elisa M; van Bruggen, David; Kukanja, Petra; Herve, Bastien; Cheng, Shangli; Kim, Eosu; Phillips, Benjamin U; Heath, Christopher J; Tripathi, Richa B; Call, Cody; Bartels, Theresa; Ridley, Katherine; Neumann, Bjorn; Lopez-Cruz, Laura; Crawford, Abbe H; Lynch, Cian J; Serrano, Manuel; Saksida, Lisa; Rowitch, David H; Möbius, Wiebke; Nave, Klaus-Armin; Rasband, Matthew N; Bergles, Dwight E; Kessaris, Nicoletta; Richardson, Willam D; Bussey, Timothy J; Zhao, Chao; Castelo-Branco, Goncalo and Franklin, Robin J M (2024). Developmental origin of oligodendrocytes determines their function in the adult brain. Nature Neuroscience, 27(8) pp. 1545–1554.

• Download Published Version (PDF / 7MB)

Colom, Morgane; Kraev, Igor; Stramek, Agata K.; Loza, Iwona B.; Rostron, Claire L.; Heath, Christopher J.; Dommett, Eleanor J. and Singer, Bryan F. (2024). Conditioning‐ and reward‐related dendritic and presynaptic plasticity of nucleus accumbens neurons in male and female sign‐tracker rats. European Journal of Neuroscience (Early access).

• Download Published Version (PDF / 4MB)

Contu, Laura; Heath, Christopher J. and Hawkes, Cheryl A. (2022). Appetitive motivation and associated neurobiology change differentially across the life course of mouse offspring exposed to peri- and postnatal high fat feeding. Nutrients, 14(23), article no. 5161.

• Download Published Version (PDF / 7MB)

Carr, Peter; Breese, Emily; Heath, Christopher J. and McMullan, Rachel (2022). The effect of the COVID-19 pandemic on disgust sensitivity in a sample of UK adults. Frontiers in Public Health, 10, article no. 1020850.

• Download Published Version (PDF / 950kB)

Lopez-Cruz, Laura and Heath, Christopher J. (2022). Motivation – Behavioral Approaches and Translational Potential. In: Della Salla, Sergio ed. Encyclopedia of Behavioral Neuroscience, 2nd edition, Volume 2. Elsevier, pp. 60–69.

Hawkes, Cheryl A.; Heath, Christopher J.; Sharp, Matthew M.; Górecki, Dariusz C. and Carare, Roxana O. (2022). α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression. Acta Neuropathologica Communications, 10, article no. 127.

• Download Published Version (PDF / 2MB)

Lopez-Cruz, Laura; Bussey, Timothy J.; Saksida, Lisa M. and Heath, Christopher (2021). Using touchscreen-delivered cognitive assessments to address the principles of the 3Rs in behavioural sciences. Lab Animal, 50 pp. 174–184.

• Download Accepted Manuscript (PDF / 968kB)

Kim, Eosu; White, Matthew A.; Phillips, Benjamin U.; Lopez-Cruz, Laura; Kim, Hyunjeong; Heath, Christopher J.; Lee, Jong Eun; Saksida, Lisa M.; Sreedharan, Jemeen and Bussey, Timothy J. (2020). Coexistence of perseveration and apathy in the TDP-43^Q331K knock-in mouse model of ALS–FTD. Translational Psychiatry, 10(1), article no. 377.

• Download Published Version (PDF / 1MB)

Heath, Christopher; O'Callaghan, Claire; Mason, Sarah L; Phillips, Benjamin U; Saksida, Lisa M; Robbins, Trevor W; Barker, Roger A; Bussey, Timothy J and Sahakian, Barbara J (2019). A touchscreen motivation assessment evaluated in Huntington’s disease patients and R6/1 model mice. Frontiers in Neurology, 10, article no. 858.

• Download Published Version (PDF / 804kB)

Hailwood, Jonathan M.; Heath, Christopher J.; Phillips, Benjamin U.; Robbins, Trevor W.; Saksida, Lisa M. and Bussey, Timothy J. (2019). Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation. Neuropsychopharmacology, 44 pp. 1068–1075.

• Download Accepted Manuscript (PDF / 944kB)

(2019). Pre- and postnatal high fat feeding differentially affects the structure and integrity of the neurovascular unit of 16-month old male and female mice. Frontiers in Neuroscience, 13, article no. 1045.

• Download Published Version (PDF / 12MB)
• Download Supplementary Material (Image (JPEG) / 413kB)
• Download Supplementary Material (Image (JPEG) / 181kB)
• Download Supplementary Material (Image (JPEG) / 285kB)
• Download Supplementary Material (PDF / 7kB)
• Download Supplementary Material (PDF / 52kB)

Nilsson, Simon R.O.; Heath, Christopher J.; Takillah, Samir; Didienne, Steve; Fejgin, Kim; Nielsen, Vibeke; Nielsen, Jacob; Saksida, Lisa M.; Mariani, Jean; Faure, Philippe; Didriksen, Michael; Robbins, Trevor W.; Bussey, Timothy J. and Mar, Adam C. (2018). Continuous performance test impairment in a 22q11.2 microdeletion mouse model: improvement by amphetamine. Translational Psychiatry, 8, article no. 247.

• Download Published Version (PDF / 1MB)

Hailwood, Jonathan M.; Heath, Christopher J.; Robbins, Trevor W.; Saksida, Lisa M. and Bussey, Timothy J. (2018). Validation and optimisation of a touchscreen progressive ratio test of motivation in male rats. Psychopharmacology, 235(9) pp. 2739–2753.

• Download Published Version (PDF / 1MB)

Phillips, Benjamin U.; Dewan, Sigma; Nilsson, Simon R. O.; Robbins, Trevor W.; Heath, Christopher J.; Saksida, Lisa M.; Bussey, Timothy J. and Alsiö, Johan (2018). Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice. Psychopharmacology, 235(7) pp. 2101–2111.

• Download Published Version (PDF / 1MB)

Kent, Brianne A.; Heath, Christopher J.; Kim, Chi Hun; Ahrens, Rosemary; Fraser, Paul E.; St George-Hyslop, Peter; Bussey, Timothy J. and Saksida, Lisa M. (2018). Longitudinal evaluation of Tau-P301L transgenic mice reveals no cognitive impairments at 17 months of age. Brain and Behavior, 8(1), article no. e00896.

• Download Published Version (PDF / 1MB)
• Download Supplementary Material (PDF / 790kB)

Phillips, Benjamin U.; Lopez-Cruz, Laura; Hailwood, Jonathan; Heath, Christopher J.; Saksida, Lisa M. and Bussey, Timothy J. (2017). Translational approaches to evaluating motivation in laboratory rodents: conventional and touchscreen-based procedures. Current Opinion in Behavioral Sciences, 22 pp. 21–27.

• Download Accepted Manuscript (PDF / 217kB)
• Download Unspecified Version (PDF / 0B)

Phillips, Benjamin U.; Heath, Christopher J.; Ossowska, Zofia; Bussey, Timothy J. and Saksida, Lisa M. (2017). Optimisation of cognitive performance in rodent operant (touchscreen) testing: Evaluation and effects of reinforcer strength. Learning and Behavior, 45(3) pp. 252–262.

• Download Published Version (PDF / 1MB)

Aitta-aho, Teemu; Phillips, Benjamin U.; Pappa, Elpiniki; Hay, Y. Audrey; Harnischfeger, Fiona; Heath, Christopher J.; Saksida, Lisa M.; Bussey, Timothy J. and Apergis-Schoute, John (2017). Accumbal cholinergic interneurons differentially influence motivation related to satiety signaling. eNeuro, 4(2), article no. e0328-16.

• Download Published Version (PDF / 2MB)

Kim, Eun Woo; Phillips, Benjamin U.; Heath, Christopher J.; Cho, So Yeon; Kim, Hyunjeong; Sreedharan, Jemeen; Song, Ho-Taek; Lee, Jong Eun; Bussey, Timothy J.; Kim, Chul Hoon; Kim, Eosu and Saksida, Lisa M. (2017). Optimizing reproducibility of operant testing through reinforcer standardization: identification of key nutritional constituents determining reward strength in touchscreens. Molecular Brain, 10, article no. 31.

• Download Published Version (PDF / 1MB)

Nilsson, Simon R. O.; Celada, Pau; Fejgin, Kim; Thelin, Jonas; Nielsen, Jacob; Santana, Noemí; Heath, Christopher J.; Larsen, Peter H.; Nielsen, Vibeke; Kent, Brianne A.; Saksida, Lisa M.; Stensbøl, Tine B.; Robbins, Trevor W.; Bastlund, Jesper F.; Bussey, Timothy J.; Artigas, Francesc and Didriksen, Michael (2016). A mouse model of the 15q13.3 microdeletion syndrome shows prefrontal neurophysiological dysfunctions and attentional impairment. Psychopharmacology

• Download Published Version (PDF / 654kB)

Heath, Christopher J.; Phillips, Benjamin U.; Bussey, Timothy J. and Saksida, Lisa M. (2016). Measuring Motivation and Reward-Related Decision Making in the Rodent Operant Touchscreen System. In: Gerfen, Charles R.; Holmes, Andrew; Sibley, David; Skolnick, Phil and Wray, Susan eds. Current Protocols in Neuroscience, Volume 74. Chichester: John Wiley & Sons, 8.34.1-8.34.20.

Jung, Yonwoo; Hsieh, Lawrence S.; Lee, Angela M.; Zhou, Zhifeng; Coman, Daniel; Heath, Christopher J.; Hyder, Fahmeed; Mineur, Yann S.; Yuan, Qiaoping and Goldman, David (2016). An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. Nature Neuroscience, 19(7) pp. 905–914.

• Download Accepted Manuscript (PDF / 76MB)

Heath, Christopher J.; Bussey, Timothy J. and Saksida, Lisa M. (2015). Motivational assessment of mice using the touchscreen operant testing system: effects of dopaminergic drugs. Psychopharmacology, 232(21) pp. 4043–4057.

• Download Published Version (PDF / 1MB)

Hvoslef-Eide, Martha; Oomen, C. A.; Fisher, B. M.; Heath, C. J.; Robbins, T. W.; Saksida, L. M. and Bussey, T. J. (2015). Facilitation of spatial working memory performance following intra-prefrontal cortical administration of the adrenergic alpha1 agonist phenylephrine. Psychopharmacology, 232(21) pp. 4005–4016.

• Download Published Version (PDF / 1MB)

Kim, Chi Hun; Romberg, Carola; Hvoslef-Eide, Martha; Oomen, Charlotte A.; Mar, Adam C.; Heath, Christopher J.; Berthiaume, Andrée-Anne; Bussey, Timothy J. and Saksida, Lisa M. (2015). Trial-unique, delayed nonmatching-to-location (TUNL) touchscreen testing for mice: sensitivity to dorsal hippocampal dysfunction. Psychopharmacology, 232(21) pp. 3935–3945.

• Download Published Version (PDF / 1MB)

Kim, Chi Hun; Heath, Christopher J.; Kent, Brianne A.; Bussey, Timothy J. and Saksida, Lisa M. (2015). The role of the dorsal hippocampus in two versions of the touchscreen automated paired associates learning (PAL) task for mice. Psychopharmacology, 232(21) pp. 3899–3910.

• Download Published Version (PDF / 3MB)

Hvoslef-Eide, M.; Mar, A. C.; Nilsson, S. R. O.; Alsiö, J.; Heath, C. J.; Saksida, L. M.; Robbins, T. W. and Bussey, T. J. (2015). The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia. Psychopharmacology

Oomen, Charlotte A.; Hvoslef-Eide, Martha; Heath, Christopher J.; Mar, Adam C.; Horner, Alexa E.; Bussey, Timothy J. and Saksida, Lisa M. (2013). The touchscreen operant platform for testing working memory and pattern separation in rats and mice. Nature Protocols, 8(10) pp. 2006–2021.

Horner, Alexa E.; Heath, Christopher J.; Hvoslef-Eide, Martha; Kent, Brianne A.; Kim, Chi Hun; Nilsson, Simon R. O.; Alsiö, Johan; Oomen, Charlotte A.; Holmes, Andrew; Saksida, Lisa M. and Bussey, Timothy J. (2013). The touchscreen operant platform for testing learning and memory in rats and mice. Nature Protocols, 8(10) pp. 1961–84.

Romberg, Carola; McTighe, Stephanie M.; Heath, Christopher J.; Whitcomb, Daniel J.; Cho, Kwangwook; Bussey, Timothy J. and Saksida, Lisa M. (2012). False recognition in a mouse model of Alzheimer's disease: rescue with sensory restriction and memantine. Brain : a journal of neurology, 135(7) pp. 2103–2114.

• Download Published Version (PDF / 574kB)

Horst, Nicole K.; Heath, Christopher J.; Neugebauer, Nichole M.; Kimchi, Eyal Y.; Laubach, Mark and Picciotto, Marina R. (2012). Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion. Behavioural Brain Research, 231(1) pp. 170–180.

Heath, Christopher J.; Horst, Nicole K. and Picciotto, Marina R. (2010). Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence. Physiology & behavior, 101(5) pp. 764–769.

Heath, Christopher J.; King, Sarah L.; Gotti, Cecilia; Marks, Michael J. and Picciotto, Marina R. (2010). Cortico-Thalamic Connectivity is Vulnerable to Nicotine Exposure During Early Postnatal Development through α4/β2/α5 Nicotinic Acetylcholine Receptors. Neuropsychopharmacology, 35(12) pp. 2324–2338.

Jacobsen, Leslie K.; Picciotto, Marina R.; Heath, Christopher J.; Mencl, W. Einar and Gelernter, Joel (2009). Allelic variation of calsyntenin 2 (CLSTN2) modulates the impact of developmental tobacco smoke exposure on mnemonic processing in adolescents. Biological Psychiatry, 65(8) pp. 671–679.

Heath, Christopher J. and Picciotto, Marina R. (2009). Nicotine-induced plasticity during development: modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing. Neuropharmacology, 56(Sup 1) pp. 254–262.

Jacobsen, Leslie K.; Picciotto, Marina R.; Heath, Christopher; Frost, Stephen J.; Tsou, Kristen A.; Dwan, Rita A.; Jackowski, Marcel P.; Constable, Robert T. and Mencl, W. Einar (2007). Prenatal and Adolescent Exposure to Tobacco Smoke Modulates the Development of White Matter Microstructure. The Journal of Neuroscience, 27(49) pp. 13491–13498.

Steiner, Rebecca C.; Heath, Christopher J. and Picciotto, Marina R. (2007). Nicotine-induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII. Journal of Neurochemistry, 103(2) pp. 666–78.

• Download Published Version (PDF / 597kB)