Currently browsing: Items authored or edited by Cheryl Hawkes https://orcid.org/0000-0001-9007-0130

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Book SectionTo Top

Kar, S. and Hawkes, C. (2007). Analysis of receptor localization in the central nervous system using in vitro and in vivo receptor autoradiography. In: Lajtha, Abel; Baker, Glenn; Dunn, Susan and Holt, Andrew eds. Handbook of Neurochemistry and Molecular Neurobiology: Practical Neurochemistry Methods. Springer, pp. 275–292.

Journal ItemTo Top

Holt, Daniel; Contu, Laura; Wood, Alice; Chadwick, Hannah; Alborelli, Ilaria; Insilla, Andrea Cacciato; Crea, Francesco and Hawkes, Cheryl A. (2024). Both Maternal High-Fat and Post-Weaning High-Carbohydrate Diets Increase Rates of Spontaneous Hepatocellular Carcinoma in Aged-Mouse Offspring. Nutrients, 16(16), article no. 2805.

Contu, Laura; Heath, Christopher J. and Hawkes, Cheryl A. (2022). Appetitive motivation and associated neurobiology change differentially across the life course of mouse offspring exposed to peri- and postnatal high fat feeding. Nutrients, 14(23), article no. 5161.

Hawkes, Cheryl A.; Heath, Christopher J.; Sharp, Matthew M.; Górecki, Dariusz C. and Carare, Roxana O. (2022). α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression. Acta Neuropathologica Communications, 10, article no. 127.

Roig-Carles, David; Willms, Eduard; Fontijn, Ruud D.; Martinez-Pacheco, Sarai; Mäger, Imre; de Vries, Helga E.; Hirst, Mark; Sharrack, Basil; Male, David K.; Hawkes, Cheryl A. and Romero, Ignacio A. (2021). Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation. Pharmaceutics, 13(9), article no. 1525.

Frias Anaya, Eduardo; Gromnicova, Radka; Kraev, Igor; Rogachevsky, Vadim; Male, David; Crea, Francesco; Hawkes, Cheryl and Romero, Ignacio A. (2021). Age-related ultrastructural neurovascular changes in the female mouse cortex and hippocampus. Neurobiology of Aging, 101 pp. 273–284.

Nizari, Shereen; Wells, Jack A.; Carare, Roxana O.; Romero, Ignacio A. and Hawkes, Cheryl A. (2021). Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice. Acta Neuropathologica Communications, 9(1), article no. 12.

Mather, Rebecca L.; Parolia, Abhijit; Carson, Sandra E.; Venalainen, Erik; Roig-Carles, David; Jaber, Mustapha; Chu, Shih‐Chun; Alborelli, Ilaria; Wu, Rebecca; Lin, Dong; Nabavi, Noushin; Jachetti, Elena; Colombo, Mario P.; Xue, Hui; Pucci, Perla; Ci, Xinpei; Hawkes, Cheryl; Li, Yinglei; Pandha, Hardev; Ulitsky, Igor; Marconett, Crystal; Quagliata, Luca; Jiang, Wei; Romero, Ignacio A; Wang, Yuzhuo and Crea, Francesco (2021). The evolutionarily conserved long non‐coding RNA LINC00261 drives neuroendocrine prostate cancer proliferation and metastasis via distinct nuclear and cytoplasmic mechanisms. Molecular Oncology, 15(7) pp. 1921–1941.

Pucci, Perla; Venalainen, Erik; Alborelli, Ilaria; Quagliata, Luca; Hawkes, Cheryl; Mather, Rebecca; Romero, Ignacio A; Rigas, Sushila; Wang, Yuzhuo and Crea, Francesco (2020). LncRNA HORAS5 promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism. Epigenomics, 12(13) pp. 1123–1138.

Alimajstorovic, Zerin; Pascual-Baixauli, Ester; Hawkes, Cheryl A.; Sharrack, Basil; Loughlin, A. Jane; Romero, Ignacio A. and Preston, Jane E. (2020). Cerebrospinal fluid dynamics modulation by diet and cytokines in rats. Fluids and barriers of the CNS, 17, article no. 10 (2020).

Contu, Laura; Carare, Roxana O. and Hawkes, Cheryl A. (2019). Knockout of apolipoprotein A‐I decreases parenchymal and vascular β‐amyloid pathology in the Tg2576 mouse model of Alzheimer's disease. Neuropathology and Applied Neurobiology, 45(7) pp. 698–714.

Nizari, Shereen; Carare, Roxana O.; Romero, Ignacio A. and Hawkes, Cheryl A. (2019). 3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain. Frontiers in Aging Neuroscience, 11, article no. 172.

(2019). Pre- and postnatal high fat feeding differentially affects the structure and integrity of the neurovascular unit of 16-month old male and female mice. Frontiers in Neuroscience, 13, article no. 1045.

Albargothy, Nazira J.; Johnston, David A.; MacGregor-Sharp, Matthew; Weller, Roy O.; Verma, Ajay; Hawkes, Cheryl A. and Carare, Roxana O. (2018). Convective infux/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways. Acta Neuropathologica, 136(1) pp. 139–152.

Horsburgh, Karen; Wardlaw, Joanna M.; van Agtmael, Tom; Allan, Stuart M.; Ashford, Mike L. J.; Bath, Philip M.; Brown, Rosalind; Berwick, Jason; Cader, M. Zameel; Carare, Roxana O.; Davis, John B.; Duncombe, Jessica; Farr, Tracy D.; Fowler, Jill H.; Goense, Jozien; Granata, Alessandra; Hall, Catherine N.; Hainsworth, Atticus H.; Harvey, Adam; Hawkes, Cheryl A.; Joutel, Anne; Kalaria, Rajesh N.; Kehoe, Patrick G.; Lawrence, Catherine B.; Lockhart, Andy; Love, Seth; Macleod, Malcolm R.; Macrae, I Mhairi; Markus, Hugh S.; McCabe, Chris; McColl, Barry W.; Meakin, Paul J.; Miller, Alyson; Nedergaard, Maiken; O'Sullivan, Michael; Quinn, Terry J.; Rajani, Rikesh; Saksida, Lisa M.; Smith, Colin; Smith, Kenneth J.; Touyz, Rhian M.; Trueman, Rebecca C.; Wang, Tao; Williams, Anna; Williams, Steven C. R. and Work, Lorraine M. (2018). Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science, 132(8) pp. 851–868.

Nizari, Shereen; Romero, Ignacio A. and Hawkes, Cheryl A. (2017). The role of perivascular innervation and neurally mediated vasoreactivity in the pathophysiology of Alzheimer's disease. Clinical Science, 131(12) pp. 1207–1214.

Morris, Alan W. J.; Sharp, Matthew MacGregor; Albargothy, Nazira J.; Fernandes, Rute; Hawkes, Cheryl A.; Verma, Ajay; Weller, Roy O. and Carare, Roxana O. (2016). Vascular basement membranes as pathways for the passage of fluid into and out of the brain. Acta Neuropathologica, 131(5) pp. 725–736.

Nizari, Shereen; Carare, Roxana O. and Hawkes, Cheryl A. (2016). Increased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat diet. Scientific reports, 6, article no. 21981.

Diem, Alexandra K.; Tan, Mingyi; Bressloff, Neil W.; Hawkes, Cheryl; Morris, Alan W. J.; Weller, Roy O. and Carare, Roxana O. (2016). A Simulation Model of Periarterial Clearance of Amyloid-β from the Brain. Frontiers in Aging Neuroscience, 8, article no. 18.

Weller, Roy O.; Hawkes, Cheryl A.; Carare, Roxana O. and Hardy, John (2015). Does the difference between PART and Alzheimer’s disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau? Acta Neuropathologica, 129(5) pp. 763–766.

Hawkes, Cheryl A.; Gentleman, Steve M.; Nicoll, James A. R. and Carare, Roxana O. (2015). Prenatal high-fat diet alters the cerebrovasculature and clearance of β-amyloid in adult offspring. Journal of Pathology, 235(4) pp. 619–631.

Weller, Roy O.; Hawkes, Cheryl A.; Kalaria, Raj N.; Werring, David J. and Carare, Roxana O. (2015). White matter changes in dementia: role of impaired drainage of interstitial fluid. Brain Pathology, 25(1) pp. 63–78.

Morris, Alan W. J.; Carare, Roxana O.; Schreiber, Stefanie and Hawkes, Cheryl A. (2014). The cerebrovascular basement membrane: Role in the clearance of β-amyloid and cerebral amyloid angiopathy. Frontiers in Aging Neuroscience, 6, article no. 251.

Maki, Takakuni; Okamoto, Yoko; Carare, Roxana O.; Hase, Yoshiki; Hattori, Yorito; Hawkes, Cheryl A.; Saito, Satoshi; Yamamoto, Yumi; Terasaki, Yasukazu; Ishibashi-Ueda, Hatsue; Taguchi, Akihiko; Takahashi, Ryosuke; Miyakawa, Taihei; Kalaria, Raj N.; Lo, Eng H.; Arai, Ken and Ihara, Masafumi (2014). Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid. Annals of Clinical and Translational Neurology, 1(8) pp. 519–533.

Carare, R. O.; Hawkes, C. A. and Weller, R. O. (2014). Afferent and efferent immunological pathways of the brain. Anatomy, Function and Failure. Brain, Behavior, and Immunity, 36 pp. 9–14.

Hawkes, Cheryl A.; Carare, Roxana O. and Weller, Roy O. (2014). Amyloid and tau in the brain in sporadic Alzheimer's disease: defining the chicken and the egg. Acta Neuropathologica, 127(4) pp. 617–618.

Hawkes, Cheryl A.; Jayakody, Nimeshi; Johnston, David A.; Bechmann, Ingo and Carare, Roxana O. (2014). Failure of perivascular drainage of β-amyloid in cerebral amyloid angiopathy. Brain Pathology, 24(4) pp. 396–403.

Hawkes, Cheryl A.; Michalski, Dominik; Anders, Rebecca; Nissel, Sabine; Grosche, Jens; Bechmann, Ingo; Carare, Roxana O. and Härtig, Wolfgang (2013). Stroke-induced opposite and age-dependent changes of vessel-associated markers in co-morbid transgenic mice with Alzheimer-like alterations. Experimental Neurology, 250 pp. 270–281.

Hawkes, C. A.; Shaw, J. E.; Brown, M.; Sampson, A. P.; McLaurin, J. and Carare, R. O. (2013). MK886 reduces cerebral amyloid angiopathy severity in TgCRND8 mice. Neurodegenerative Diseases, 13(1) pp. 17–23.

Carare, R. O.; Hawkes, C. A.; Jeffrey, M.; Kalaria, R. N. and Weller, R. O. (2013). Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy. Neuropathology and Applied Neurobiology, 39(6) pp. 593–611.

Carare, Roxana Octavia; Teeling, Jessica Liesbeth; Hawkes, Cheryl A.; Püntener, Ursula; Weller, Roy O.; Nicoll, James A. R. and Perry, Victor Hugh (2013). Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer's disease. Acta neuropathologica communications, 1(1), article no. 48.

Dorr, Adrienne; Sahota, Bhupinder; Chinta, Lakshminarayan V.; Brown, Mary E.; Lai, Aaron Y.; Ma, Keran; Hawkes, Cheryl A.; McLaurin, JoAnne and Stefanovic, Bojana (2012). Amyloid-β-dependent compromise of microvascular structure and function in a model of Alzheimer's disease. Brain, 135(10) pp. 3039–3050.

Amritraj, Asha; Posse de Chaves, Elena I.; Hawkes, Cheryl; MacDonald, Richard G. and Kar, Satyabrata (2012). Single-transmembrane domain IGF-II/M6P receptor: potential interaction with G protein and its association with cholesterol-rich membrane domains. Endocrinology, 153(10) pp. 4784–4798.

Hawkes, Cheryl A.; Deng, LeHua; Fenili, Daniela; Nitz, Mark and McLaurin, JoAnne (2012). In vivo uptake of β-amyloid by non-plaque associated microglia. Current Alzheimer Research, 9(8) pp. 890–901.

Hawkes, Cheryl A.; Sullivan, Patrick M.; Hands, Sarah; Weller, Roy O.; Nicoll, James A. R. and Carare, Roxana O. (2012). Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele. PLoS ONE, 7(7), article no. e41636.

Finney, Constance A. M.; Hawkes, Cheryl A.; Kain, Dylan C.; Dhabangi, Aggrey; Musoke, Charles; Cserti-Gazdewich, Christine; Oravecz, Tamas; Liles, W. Conrad and Kain, Kevin C. (2011). S1P is associated with protection in human and experimental cerebral malaria. Molecular Medicine, 17(7-8) pp. 717–725.

Hawkes, Cheryl A.; Härtig, Wolfgang; Kacza, Johannes; Schliebs, Reinhard; Weller, Roy O.; Nicoll, James A. and Carare, Roxana O. (2011). Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy. Acta Neuropathologica, 121(4) pp. 431–443.

Hawkes, Cheryl A.; Deng, Le-Hua; Shaw, James E.; Nitz, Mark and McLaurin, JoAnne (2010). Small molecule β-amyloid inhibitors that stabilize protofibrillar structures in vitro improve cognition and pathology in a mouse model of Alzheimer's disease. European Journal of Neuroscience, 31(2) pp. 203–213.

Hawkes, Cheryl A.; Ng, Vivian and McLaurin, JoAnne (2009). Small molecule inhibitors of Aβ-aggregation and neurotoxicity. Drug Development Research, 70(2) pp. 111–124.

Hawkes, Cheryl and McLaurin, JoAnne (2009). Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy. Proceedings of the National Academy of Sciences of the United States of America, 106(4) pp. 1261–1266.

Amritraj, A.; Hawkes, C.; Phinney, A. L.; Mount, H. T.; Scott, C. D.; Westaway, D. and Kar, S. (2009). Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP + PS1 transgenic mouse brains. Neurobiology of Aging, 30(1) pp. 54–70.

Sun, Yedi; Zhang, Guohau; Hawkes, Cheryl A.; Shaw, James E.; McLaurin, JoAnne and Nitz, Mark (2008). Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation. Bioorganic & Medicinal Chemistry, 16(15) pp. 7177–7184.

Hawkes, Cheryl A. and McLaurin, JoAnne (2008). Clinical immunotherapy trials in Alzheimer's disease. Drug Discovery Today: Therapeutic Strategies, 5(3) pp. 177–183.

Lovegrove, Fiona E.; Gharib, Sina A.; Patel, Samir N.; Hawkes, Cheryl A.; Kain, Kevin C. and Liles, W. Conrad (2007). Expression microarray analysis implicates apoptosis and interferon-responsive mechanisms in susceptibility to experimental cerebral malaria. American Journal of Pathology, 171(6) pp. 1894–1903.

Hawkes, Cheryl A. and McLaurin, JoAnne (2007). Immunotherapy as treatment for Alzheimer's disease. Expert Review of Neurotherapeutics, 7(11) pp. 1535–1548.

Hawkes, C.; Amritraj, A.; MacDonald, R. G.; Jhamandas, J. H. and Kar, S. (2007). Heterotrimeric G proteins and the single-transmembrane domain IGF-II/M6P receptor: functional interaction and relevance to cell signaling. Molecular Neurobiology, 35(3) pp. 329–345.

Dikkes, P.; Hawkes, C.; Kar, S. and Lopez, M. F. (2007). Effect of kainic acid treatment on insulin-like growth factor-2 receptors in the IGF2-deficient adult mouse brain. Brain Research, 1131(1) pp. 77–87.

Hawkes, Cheryl; Kabogo, Doreen; Amritraj, Asha and Kar, Satyabrata (2006). Up-regulation of cation-independent mannose 6-phosphate receptor and endosomal-lysosomal markers in surviving neurons after 192-IgG-saporin administrations into the adult rat brain. American Journal of Pathology, 169(4) pp. 1140–1154.

McLaurin, JoAnne; Kierstead, Meredith E.; Brown, Mary E.; Hawkes, Cheryl A.; Lambermon, Mark H. L.; Phinney, Amie L.; Darabie, Audrey A.; Cousins, Julian E.; French, Janet E.; Lan, Melissa F.; Chen, Fusheng; Wong, Sydney S.N.; Mount, Howard T. J.; Fraser, Paul E.; Westaway, David and St. George-Hyslop, Peter (2006). Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nature Medicine, 12(7) pp. 801–808.

Li, Tong; Hawkes, Cheryl; Quereshi, Hamid Y.; Kar, Satyabrata and Paudel, Hemant K. (2006). Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3β. Biochemistry, 45(10) pp. 3134–3145.

Kar, S.; Poirier, J.; Guevara, J.; Dea, D.; Hawkes, C.; Robitaille, Y. and Quirion, R. (2006). Cellular distribution of insulin-like growth factor-II/mannose-6-phosphate receptor in normal human brain and its alteration in Alzheimer's disease pathology. Neurobiology of Aging, 27(2) pp. 199–210.

Hawkes, Cheryl; Jhamandas, Jack H.; Harris, Kim H.; Fu, Wen; MacDonald, Richard G. and Kar, Satyabrata (2006). Single transmembrane domain insulin-like growth factor-II/mannose-6- phosphate receptor regulates central cholinergic function by activating a G-protein-sensitive, protein kinase C-dependent pathway. Journal of Neuroscience, 26(2) pp. 585–596.

Hawkes, Cheryl; Jhamandas, J.H. and Kar, S. (2005). Selective loss of basal forebrain cholinergic neurons by 192 IgG-saporin is associated with decreased phosphorylation of Ser9 glycogen synthase kinase-3β. Journal of Neurochemistry, 95(1) pp. 263–272.

Hawkes, Cheryl and Kar, S. (2004). The insulin-like growth factor-II/mannose-6-phosphate receptor: structure, distribution and function in the central nervous system. Brain Research Reviews, 44(2-3) pp. 117–140.

Hawkes, Cheryl and Kar, Satyabrata (2003). Insulin-like growth factor-II/mannose-6-phosphate receptor: Widespread distribution in neurons of the central nervous system including those expressing cholinergic phenotype. Journal of Comparative Neurology, 458(2) pp. 113–127.

Hawkes, Cheryl and Kar, S. (2002). Insulin-like growth factor-II/Mannose-6-phosphate receptor in the spinal cord and dorsal root ganglia of the adult rat. European Journal of Neuroscience, 15(1) pp. 33–39.

Conference or Workshop ItemTo Top

Latarani, Maryam; Pucci, Perla; Roig-Carles, David; Eccleston, Mark; Xue, Hui; Hawkes, Cheryl; Rigas, Sushila; Wang, Yuzhuo and Crea, Francesco (2020). EZH2 as a therapeutic target for aggressive prostate cancer. In: Crick Cancer Research Symposium, iPoster, 5-6 Oct 2020, The Francis Crick Institute and Virtual.

Rich, Steven A.; Carare, Roxana O.; Snyder, Peter J. and Hawkes, Cheryl A. (2019). The Case For Cholinesterase Inhibition To Modify Neurodegenerative Diseases Through The Intramural Periarterial Drainage Of The Cns (IPAD). In: Alzheimer's & Dementia, Elsevier, 15(7) P926.

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