Browse by Partner Institution Thesis

Number of items at this level: 134.
Generated on Tue Sep 10 11:57:21 2024 BST.

2024To Top

Margotta, Cassandra (2024). More than a Bystander: The Contribution of the Skeletal Muscle as Source of Biomarkers and Molecular Targets in Amyotrophic Lateral Sclerosis. PhD thesis The Open University.

2023To Top

Allocati, Eleonora (2023). Optimizing The Clinical Efficacy And Safety Of Biological Medicines And Their Biosimilars Within Available Resources In Europe. PhD thesis The Open University.

Di Sapia, Rossella (2023). Biomarkers of Epileptogenesis and Novel Therapeutic Approaches in Animal Models of Acquired Epilepsy. PhD thesis The Open University.

Kebede, Valentina (2023). Healthy life-style interventions to attain disease modifications in acquired epilepsy. PhD thesis The Open University.

Kelk, Joe (2023). Perivascular Macrophages in ischaemic endothelial function. PhD thesis The Open University.

Masone, Antonio (2023). Mechanism of Prion Protein (PrP) Degradation Induced by a Tetracationic-porphyrin: Implications for the Therapy of Prion Diseases. PhD thesis The Open University.

Passoni, Alice (2023). Innovative Therapeutic Strategy Targeting Neurons with Cholesterol in Huntington’s Disease: From Preclinical Studies to Clinical Trial Readiness. PhD thesis The Open University.

Ruggeri, Laura (2023). Improving Outcome After Cardiac Arrest: New Pharmacological And Electrophysiological Approaches During Cardiopulmonary Resuscitation. PhD thesis The Open University.

Vegliante, Gloria (2023). Studies in Mice and Patients to Understand the Role of Tau Pathology in Driving Neurodegeneration After Traumatic Brain Injury. PhD thesis The Open University.

2022To Top

Mannarino, Laura (2022). Multi-omics Characterisation of Myxoid Liposarcoma and Investigation of Trabectedin Mechanism of Action for Its Treatment. PhD thesis The Open University.

Pesenti, Chiara (2022). Genomic and Epigenomic study of Stage I Epithelial Ovarian Carcinomas to Implement Novel Prognostic Molecular Biomarkers. PhD thesis The Open University.

Sironi, Francesca (2022). Loss of C9orf72 Function Impairs the Peripheral Neuromuscular System and Anticipates Symptoms in ALS Mice. PhD thesis The Open University.

2021To Top

Di Nunzio, Martina (2021). Pharmacological Approaches To Study and Counteract Epileptogenesis in Acquired Epilepsy: Focus on the Role of Microglia. PhD thesis The Open University.

Guffanti, Federica (2021). DNA Repair and Response to Therapy: Exploring their Relation in Epithelial Ovarian Cancer Models. PhD thesis The Open University.

Moradi Bachiller, Soraya (2021). Preclinical and Clinical Early Alzheimer's Disease (AD) Biomarker Discovery Using Proteins and MicroRNAs Carried by Small Extracellular Vesicles (sEVs). PhD thesis The Open University.

Pansieri, Claudia (2021). The Development and Running of an Italian Birth Cohort for an In-Depth Evaluation of Child Health Status and Health Care Utilization in the First Years of Life. MPhil thesis The Open University.

Trolese, Maria Chiara (2021). Targeting Motor Neuron - Immune System Crosstalk to Modulate the Disease Progression in Amyotrophic Lateral Sclerosis Mouse Model. PhD thesis The Open University.

2020To Top

Fusco, Federica (2020). Investigation of Sirtuins as Therapeutic Targets in Neurodegenerative Disorders: Studies on Mechanisms and Possible Combined Therapy. PhD thesis The Open University.

La Vitola, Pietro (2020). Neuroinflammation and Alpha-Synuclein Oligomer Toxicity in the Pathogenesis of Lewy Body Dementia and Parkinson's Disease. PhD thesis The Open University.

Paracchini, Lara (2020). Analysis of Defects in Transcriptional Regulation Mechanisms in High-Grade Serous Ovarian Cancer and Their Correlation with Clinic-Pathological Features. PhD thesis The Open University.

Porcu, Luca (2020). Preclinical In Vivo Antitumor Activity Experiments: Methodological Pitfalls and a New Framework for their Design and Analysis. PhD thesis The Open University.

Pozzer, Diego (2020). Unravelling the Role of Ascorbic Acid and ER Stress in SEPN1-Related Myopathy. PhD thesis The Open University.

Talamini, Laura (2020). The Influence Of The Material And The Geometry Of Nanoparticles On Their Organ Distribution And Biological Barrier Passage. PhD thesis The Open University.

2019To Top

Bizzaro, Francesca (2019). Preclinical Models to study the Biology and Therapy of Ovarian Cancer. PhD thesis The Open University.

Celestini, Valentina (2019). Exploiting the Mitochondrial Fox 03A/SIRT3 Complex in Cancer Therapy. PhD thesis The Open University.

Finazzi, Stefano (2019). Mathematical Models for Optimisation of Drug Administration in Intensive Care Units. PhD thesis The Open University.

Romeo, Margherita (2019). Elucidation of the Molecular Mechanisms Underlying the Ability of C. Elegans Pharynx to Recognize as Toxicant the Soluble, Pre-Fibrillar Assemblies of the Amyloidogenic Proteins. PhD thesis The Open University.

Tolomeo, Daniele (2019). Development of a Multimodal MRI Study to Characterize Morpho-Functional Features in Rodent Models of Alzheimer's Disease. PhD thesis The Open University.

2018To Top

Brizi, Valerio (2018). Engineering Complex Kidney Structures for Disease Modelling, Drug Testing, and Studying Kidney Development. PhD thesis The Open University.

Fumagalli, Francesca Maria (2018). Preclinical Optimization of Treatment with Inhaled Argon to Improve Neurological Outcome and Survival After Cardiac Arrest. PhD thesis The Open University.

Giussani, Giorgia (2018). Observational and Experimental Studies on the Diagnosis and Outcome of Epilepsy and Epileptogenic Conditions: Investigating the Static and Dynamic Phenotype of Epilepsy. PhD thesis The Open University.

Golbamaki Bakhtyari, Azadi (2018). Integration of Toxicity Data from Experiments and Non-Testing Methods within a Weight of Evidence Procedure. PhD thesis The Open University.

Kostoula, Chrysavgi (2018). Investigating Inflammatory Pathways as Therapeutic Targets and Biomarkers using Functional Imaging and Pharmacological Interventions in Epilepsy Models. PhD thesis The Open University.

Piovani, Daniele (2018). Determinants Of Drug Utilisation During Childhood. PhD thesis The Open University.

Piras, Rossella Alberta (2018). Genetic and Acquired Abnormalities in C3 Glomerulopathy and Primary Immune Complex-Mediated MPGN. PhD thesis The Open University.

Valoti, Elisabetta (2018). Genetic Factors Associated with Anti-Factor H Autoantibodies in Atypical Hemolytic Uremic Syndrome (aHUS). PhD thesis The Open University.

2017To Top

Bettoni, Serena (2017). Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System. PhD thesis The Open University.

Frigerio, Federica (2017). Identifying Key Regulators of the Immune/Inflammatory Response for Developing Anticonvulsive and Antiepileptogenic Approaches. PhD thesis The Open University.

Iatropoulos, Paraskevas (2017). Next-Generation Sequencing for New Gene Identification and for Diagnosis in Steroid-Resistant Nephrotic Syndrome. PhD thesis The Open University.

Moro, Federico (2017). Evaluation of Glutamatergic Treatment in Reducing Nicotine Seeking Behavior in Rats. PhD thesis The Open University.

Papa, Simonetta Giulia (2017). Characterization of a Nanoparticle Drug Delivery System for the Treatment of Inflammation in Spinal Cord Injury. PhD thesis IRCCS - Istituto di Ricerche Farmacologiche Mario Negri.

Rousis, Nikolaos (2017). Identification and Screening of Biomarkers of Human Exposure to Environmental and Food Toxicants in Sewage. PhD thesis The Open University.

Stravalaci, Matteo (2017). Identification And Characterization Of Mediators Of Toxicity Of Aβ Oligomers By Genome Wide Screening In Caenorhabditis Elegans. PhD thesis The Open University.

Uboldi, Sarah (2017). Identification Of Effective New Drugs Combinations Exploiting The Ability Of trabectedin To Modulate Transcription. PhD thesis The Open University.

2016To Top

Franzoni, Marco (2016). The Role of Wall Shear Stress in the Failure of Arteriovenous Fistula for Hemodialysis Vascular Access. PhD thesis The Open University.

2015To Top

Baderna, Diego (2015). Ecological and human-related in vitro bioassays as supporting tools for the chemical-based risk assessment of environmental mixtures : selection of the test battery and three case studies. PhD thesis The Open University.

Caiola, Elisa (2015). Impact of different KRAS mutations on tumour progression and drug sensitivity in non-small-cell lung cancer. The Open University.

Diaza, Rodolfo Gonella (2015). Development of New Methods for the (Q)SAR Applicability Domain Assessment: Using Structural Information in a Statistical Study of the Errors in Prediction. PhD thesis The Open University.

2014To Top

Fisher, James Neil (2014). Therapeutic activity of retinoic acid and derivatives in breast carcinoma : the role of microRNAs. PhD thesis The Open University.

Golbamaki Bakhtyari, Nazanin (2014). Development, assessment and implementation of computer based predicitve models for evaluation of genotoxicity and carcinogenicity of chemicals. PhD thesis The Open University.

Moja, Lorenzo P. (2014). A continuing medical education program based in high quality evidence to transfer knowledge and to improve practice for health care professionals. PhD thesis The Open University.

Orsini, Franca (2014). Mannose binding lectin : a potential new target for acute brain injury. PhD thesis The Open University.

Rizzo, Paola (2014). Cellular mechanisms underlying the ACE inhibitor capacity to stimulate kidney self-repair. PhD thesis The Open University.

Rusconi, Paolo (2014). Characterization of DRAGO : a gene with potential tumour suppressive function. PhD thesis The Open University.

Sitia, Leopoldo (2014). Evaluation of biocompatible polymeric nanoparticles in healthy and diseased organisms : focus on triple negative breast cancer. PhD thesis The Open University.

2013To Top

Decio, Alessandra Agnese (2013). The VEGFC/VEGFR3 pathway in the malignancy of ovarian carcinoma. PhD thesis The Open University.

Fumagalli, Stefano (2013). Studies on Vascular Changes and Immune Cell Role in the Ischemic Brain By In Vivo Two-Photon Microscopy. PhD thesis The Open University.

Lauranzano, Eliana (2013). Study of Cyclophilin A Function in Models of Amyotrophic Lateral Sclerosis. PhD thesis The Open University.

Marino, Marianna (2013). Comparative analysis of protein quality control systems in two mouse models of familial amyotrophic lateral sclerosis. PhD thesis The Open University.

Ricci, Francesca (2013). Molecular determinants of the response to therapy in ovarian cancer. PhD thesis The Open University.

Ristagno, Giuseppe (2013). Biochemical and electrophysiological markers predictive of return of spontaneous circulation and post-resuscitation outcome. PhD thesis The Open University.

Rota, Cinzia (2013). Effect of Foetal and Adult Stem Cells in Acute and Chronic Kidney Diseases. PhD thesis The Open University.

Rurali, Erica (2013). ADAMTS13 polymorphisms : role in predicting renal and cardiovascular events in type 2 diabetes and response to therapy. PhD thesis The Open University.

Scornavacca, Giacomo Maria (2013). An integrated proteomic and metabolomic approach to investigate cerebral ischemic preconditioning. PhD thesis The Open University.

2012To Top

Brunelli, Dario (2012). Use of genetically engineered bacteria to activate prodrugs in tumours. PhD thesis The Open University.

Caron, Ilaria (2012). Use of magnetic resonance imaging (MRI) to monitor disease progression in animal models of familial amyotrophic lateral sclerosis. PhD thesis The Open University.

Di Giandomenico, Silvana (2012). Mode of Action of Trabectedin in Human Mixoid Liposarcoma Growing in Immunodeficient Mice: Evidence that the Drug Acts by Displacing FUS-CHOP Chimeric Protein From its Target Promoters. PhD thesis The Open University.

Mohammed, Salman Afroze Azmi (2012). Modulation of myocardium repair after ischemic injury: role of macrophages. PhD thesis The Open University.

Parabiaghi, Alberto (2012). Aripiprazole, Olanzapine and Haloperidol in the Long-Term Treatment of Schizophrenia: The Rationale and Development of the GiSAS Pragmatic Randomized Controlled Trial, a Consideration and Empirical Study of Factors Associated With Recruitment (the GiSAS Survey) and the Concept of Endpoints Using a Secondary Analysis of Existing Data and a Preliminary Analysis of GiSAS Trial Data. PhD thesis The Open University.

Polito, Letizia (2012). Genetic and environmental factors affecting Alzheimer's disease pathogenic mechanism: the role of sirtuins. PhD thesis The Open University.

Sclip, Alessandra (2012). c-Jun N-terminal kinase regulates Aβ oligomers production, synapthopathy and cognitive deficits in Alzheimer's disease. PhD thesis The Open University.

2011To Top

Boriani, Elena (2011). Assessing the environmental risks associated with contaminated sites. PhD thesis The Open University.

Campagna, Roberta (2011). Neurotoxic effects of the environmental non-dioxin-like PCBs using a proteomic approach. PhD thesis The Open University.

Mazzoletti, Marco (2011). Evaluation of the activity of a new class of PI3K-pathway inhibitors. PhD thesis The Open University.

Mele, Caterina (2011). Identitication of new genes involved in focal segmental glomerulosclerosis and nephrotic syndrome. PhD thesis The Open University.

Pozzi, Laura (2011). Role of the Transcription Factor CREB in the NMDA Receptor Antagonist-Induced Attention Deficits. PhD thesis The Open University.

Pozzi, Silvia (2011). Amyotropic lateral sclerosis : identification of common protein biomarkers in patients and rodent models. PhD thesis The Open University.

Previdi, Sara (2011). HGF/C-MET in breast-cancer bone metastasis : characterization and imaging analysis to evaluate the efficacy of traget therapies. PhD thesis The Open University.

2010To Top

Agnoli, Laura (2010). Modulation of cortical cognitive functions by dopamine and serotonin receptors in the dorsal striatum. PhD thesis The Open University.

Beeg, Marten (2010). Tetracycline and its Analogues as Drugs Against Protein Aggregation and Amyloid Formation. PhD thesis The Open University.

Clavenna, Antonio (2010). Drug Use in Outpatient Children: Epidemiological Evaluations. PhD thesis The Open University.

Gesuete, Raffaella (2010). Identification of ischemic tolerance mediators in acute brain injury. PhD thesis The Open University.

Godman, Brian Barr (2010). Evaluating the impact of generic prescribing to improving the cost-effectiveness of drug use in ambulatory care throughout Europe. PhD thesis The Open University.

Gutierrez, Karel Otero (2010). Study of the biological function of the putative murine chemokine receptor CCRL2. PhD thesis The Open University.

Manzoni, Claudia (2010). The role of misfolding proteins in amyloid neurotoxicity : the relevance of oligomers in membrane alterations. PhD thesis The Open University.

Marangon, Elena (2010). Evaluation of the pharmacokinetic properties of new taxane derivatives. PhD thesis The Open University.

Peviani, Marco (2010). Development of lentiviral vectors targeted to P38MAPK inhibition and Akt activation in motor neurons of a mouse model of familial amyotrophic lateral sclerosis. PhD thesis The Open University.

Schiarea, Silvia (2010). Mass spectrometry-based characterisation of the secretome of pancreatic cancer cell lines. PhD thesis The Open University.

Senatore, Assunta (2010). Analysis of synaptic dysfuntion of a transgenic mouse model of inherited prion disease. PhD thesis The Open University.

Silini, Antonietta (2010). Molecular profile of the stroma from human ovarian carcinoma xenograft tumours equipped with different angiogenic phenotypes. PhD thesis The Open University.

2009To Top

Balosso, Silvia (2009). Targeting Cytokine Systems to Achieve Neuroprotection: Experimental Models of Seizures and Neurodegeneration. PhD thesis The Open University.

Calcagno, Eleonora (2009). Resistance to selective serotonin reuptake inhibitors: role of serotonergic mechanisms. PhD thesis The Open University.

Carpi, Donatella (2009). Effect of Dioxin on Bone Cell Proteome. PhD thesis The Open University.

Cornolti, Roberta (2009). Transplantation of Pancreatic Islet in an Immunoisolation Device. PhD thesis The Open University.

Cravedi, Paolo (2009). A Prospective, Randomized Study to Compare the Effect of Combination Therapy With Campath-1H on Peripheral Blood Mononuclear Cells in Kidney Transplant Recipients. PhD thesis The Open University.

De Paola, Massimiliano (2009). In Vitro Studies on AMPA Receptor-Mediated Motor Neuron Death: Relevance for Amyotrophic Lateral Sclerosis. PhD thesis The Open University.

Massignan, Tania (2009). Analysis of the toxic cellular pathways activated by mutant prion proteins. PhD thesis The Open University.

Noè, Francesco Mattia (2009). Hippocampal neuropeptide Y (NPY) gene transfer as a therapeutic strategy for temporal lobe epilepsy. PhD thesis The Open University.

2008To Top

Buelli, Simona (2008). Role of complement in tubular cell activation and injury. PhD thesis The Open University.

Cassis, Paola (2008). Donor engineering dendritic cells to generate tolerogenic regulatory T cells for renal transplantation. PhD thesis The Open University.

Cheroni, Cristina (2008). The role of proteasome dysfunction in the mechanisms of motor neuron degeneration in a mouse model of familial amyotrophic lateral sclerosis. PhD thesis The Open University.

Fumagelli, Elena (2008). Glutamate uptake by presynaptic compartment in motor neuron degeneration. PhD thesis The Open University.

Roncaglioni, Alessandro (2008). Data exploration and knowledge extraction: their application to the study of endocrine disrupting chemicals. PhD thesis The Open University.

Sabatino, Maria Antonietta (2008). Combination treatments in in vitro and in vivo models between molecules reverting epigenetic gene silencing and DNA-interacting anticancer drugs. PhD thesis The Open University.

2007To Top

Bonecchi, Raffaella (2007). Identification Of New Molecules Involved In Dendritic Cell Localization. PhD thesis The Open University.

Rizzi, Massimo (2007). Role of selected aspects of inflammation in age-dependent seizure susceptibility and neuronal injury in rats. PhD thesis The Open University.

Serafini, Marta (2007). Preclinical development of the CD20 suicide gene system. PhD thesis The Open University.

Storini, Claudio (2007). Complement and related inflammatory systems in ischemia/reperfusion brain injury. PhD thesis The Open University.

Veglianese, Peitro (2007). Sub-cellular localization and regulatory mechanisms of AMPA receptors in motor neurons of a murine model of familial Amyotrophic Lateral Sclerosis. PhD thesis The Open University.

2006To Top

Carli, Mirjana (2006). Serotonergic modulation of attentional processes in the rat prefrontal cortex. PhD thesis The Open University.

Carrassa, Laura (2006). Molecular mechanisms regulating the G2 checkpoint induced after DNA damage. PhD thesis The Open University.

Cattaneo, Dario (2006). Therapeutic drug monitoring of novel immunosuppressants. PhD thesis The Open University.

Gagliardini, Elena (2006). Role of nephrin in the glomerular permselectivity. PhD thesis The Open University.

Ghezzi, Pietro (2006). Protein glutathionylation in the redox regulation of immunity. PhD thesis The Open University.

Imberti, Barbara (2006). Bone marrow stem cells to regenerate injured murine renal tissue. PhD thesis The Open University.

Lupi, Monica (2006). Evaluation of the complexity of cell cycle effects induced by anticancer drugs. PhD thesis The Open University.

Marchesi, Federica (2006). Chemokines and their receptors in the metastatic behaviour of human pancreatic ductal adenocarcinoma. PhD thesis The Open University.

Polato, Federica (2006). Identification and characterisation of new genes important for p53- dependent, stress-induced apoptosis. PhD thesis The Open University.

Schioppa, Tiziana (2006). Effects of tumour hypoxia on cell migration. PhD thesis The Open University.

2005To Top

Bigini, Paolo (2005). The role of apoptosis in in vitro and in vivo models of amyotrophic lateral sclerosis. PhD thesis The Open University.

Bosisio, Daniela (2005). The TIR superfamily of immune receptors : distribution, regulation and mechanisms of cellular activation. PhD thesis The Open University.

Calvillo, Laura (2005). Ischemic cardiac damage : inflammation, repair processes and their pharmacological modulation. PhD thesis The Open University.

Fioriti, Luana (2005). The role of abnormal forms of the prion protein in the pathogenesis of inherited prion diseases. PhD thesis The Open University.

Floriani, Irene Claudia (2005). Statistical approaches to interim analysis : a critical appraisal. PhD thesis The Open University.

Marabese, Mirko (2005). Mechanisms of activation of the p53-related gene p73 and its role in cancer cell growth. PhD thesis The Open University.

Mazzatorta, Paolo (2005). Evaluation of pesticide toxicity: a hierarchical QSAR approach to model the acute aquatic toxicity and avian oral toxicity of pesticides. PhD thesis The Open University.

Naumova, Elitza (2005). Investigation of the antiangiogenic effect of SU6668, a receptor tyrosine kinase (RTK) inhibitor, in combination with paclitaxel, a chemotherapeutic agent. PhD thesis The Open University.

Pandolfini, Chiara Liz (2005). Development of a pan-European register of clinical trials on drug therapy in children. PhD thesis The Open University.

Quaglio, Elena (2005). Development and Characterisation of PC12 Cell Lines Allowing Inducible Expression of Prion Proteins Carrying Pathogenic Mutations. PhD thesis The Open University.

Tortarolo, Massimo (2005). Role of excitotoxicity in the degeneration of motor neurones in ALS. PhD thesis The Open University.

2004To Top

Bani, Maria Rosa (2004). Influence of the tumour environment on endothelium : identification of targets for the development of anti-vascular therapy. The Open University.

Cervo, Luigi (2004). Cocaine-seeking behaviour by drug associated stimuli : reversal by dopamine D₃ partial agonists and antagonists. PhD thesis The Open University.

2003To Top

Spagnuolo, Raffaella (2003). Role of VE-cadherin in endothelial cell survival. PhD thesis The Open University.

2002To Top

Marchini, Sergio (2002). Molecular characterisation of a novel class of DNA minor groove binders with promising anti-tumor activity. The Open University.

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