Browse by Partner Institution Thesis

Number of items at this level: 104.
Generated on Sat Jan 18 03:19:02 2025 GMT.

2013To Top

Cantore, Alessio (2013). Development of a Liver Gene Therapy Strategy for Haemophilia B With Lentiviral Vectors. Doctor of Philosophy (PhD) thesis The Open University.

2012To Top

Campana, Lara (2012). Leukocyte HMGB1 Guides Neoangiogenesis in Regenerating Skeletal Muscle. Doctor of Philosophy (PhD) thesis The Open University.

Casucci, Monica (2012). Dual transgenesis of T cells with a CD44v6-specific chimeric antigen receptor and a suicide gene for the safe eradication of chemoresistant leukaemia and myeloma. Doctor of Philosophy (PhD) thesis The Open University.

Corre, Tanguy (2012). Genetics of premature ovarian failure and early menopause. Doctor of Philosophy (PhD) thesis The Open University.

Ornaghi, Francesca (2012). Analysis of the role of the cytoplasmic tail of P0 glycoprotein in a mouse model of Congenital Hypomyelination neuropathy. Doctor of Philosophy (PhD) thesis The Open University.

Pellegatta, Marta (2012). An in vivo and in vitro study on the role of different integrins and their effectors in laminin-driven peripheral nervous system myelination. Doctor of Philosophy (PhD) thesis The Open University.

Ranzani, Marco (2012). High throughput lentiviral vector-based oncogene tagging for the discovery of liver cancer genes. Doctor of Philosophy (PhD) thesis The Open University.

Spiliotopoulos, Dimitrios (2012). Computational and experimental approaches on NSD1and AIRE PHD fingers : structures, functions and thermodynamics. Doctor of Philosophy (PhD) thesis The Open University.

Squadrito, Mario Leonardo (2012). miR-511-3p modulates the protumoral properties of tumor associated macrophages. Doctor of Philosophy (PhD) thesis The Open University.

Vassena, Lia (2012). Anti-apoptotic effects of Interleukin 7 in Human Immunodeficiency Virus Type 1 infection: Mechanism and implications for immune reconstitution strategies. Doctor of Philosophy (PhD) thesis The Open University.

2011To Top

Cabiannca, Daphne Selvaggia (2011). An RNA regulates the epigenetic switch at the basis of FSHD. Doctor of Philosophy (PhD) thesis The Open University.

Lombardo, Angelo Leone (2011). Developing safer gene therapy approaches by zinc finger nucleases-mediated gene editing. Doctor of Philosophy (PhD) thesis The Open University.

Magri, Laura (2011). Functional and molecular characterization of the role of mTOR pathway in neural stem cells both in vivo and in vitro. Doctor of Philosophy (PhD) thesis The Open University.

Palmigiano, Angela (2011). Dissecting the downstream pathway of OA1, an unconventional G protein-coupled receptor involved in melanosome biogenesis and transport. Doctor of Philosophy (PhD) thesis The Open University.

Santambrogio, Sara (2011). Neural Stem Cell Compartments in a Mouse Model of Globoid Cell Leukodystrophy: Implication for Therapeutic Strategies. Doctor of Philosophy (PhD) thesis The Open University.

Tomasoni, Romana (2011). TSC/mTOR Signalling Controls Thymocyte Development and Proliferation/Differentiation of T Lymphocytes and Nerve Cells. Doctor of Philosophy (PhD) thesis The Open University.

2010To Top

Bernascone, Ilenia (2010). Generation of mouse models for uromodulin-associated kidney diseases : renal function defect and tubulointerstitial damage upon expression of transgenic mutant protein. Doctor of Philosophy (PhD) thesis The Open University.

Biasco, Luca (2010). Uncovering cell-specific integration profiles of retroviral vector dependent on genetic epigenetic factors of target cells in ADA-SCID patients treated with mature lymphocytes or haemopoietic stem cell gene therapy. Doctor of Philosophy (PhD) thesis The Open University.

Catucci, Marco (2010). Evaluation of dendritic cell functionality in gene therapy was⁻/⁻ mice and characterisation of novel dendritic cell defects in characterisation of dendritic cells in was⁻/⁻ mice. Doctor of Philosophy (PhD) thesis The Open University.

Celona, Barbara (2010). Effects of HMGB1 dosage on chromatin packaging : tuning histone expression, nucleosome number and positioning. Doctor of Philosophy (PhD) thesis The Open University.

Cesana, Daniela (2010). Gene therapy vectors : towards a safe design for clinical applications. Doctor of Philosophy (PhD) thesis The Open University.

Di Cesare, Alessandra (2010). Molecular characterisation of activated astrocytes and their role in neurodegeneration. Doctor of Philosophy (PhD) thesis The Open University.

Dondossola, Eleonora (2010). Molecular mechanisms of chromogranin A in cell adhesion and tumor biology. Doctor of Philosophy (PhD) thesis The Open University.

Fornasiero, Eugenio Francesco (2010). Membrane traffic in neurons : establishment of polarity, axonal development and synaptic organisation. Doctor of Philosophy (PhD) thesis The Open University.

Mariani, Samantha Antonella (2010). Host and viral determinants of HIV-1 co-receptor usage. Doctor of Philosophy (PhD) thesis The Open University.

Marzorati, Patrizia (2010). Characterisation of hematopoietic stem/progenitor cells and their mobilization in uPAR KO mice. Doctor of Philosophy (PhD) thesis The Open University.

Masserdotti, Giacomo (2010). ZFP423 Coordinates Notch Pathway, Bmp Signaling and EBF/COE Transcription Factors to Regulate Hes5 Gene Expression. Doctor of Philosophy (PhD) thesis The Open University.

Mori, Silvia (2010). Biochemical and Functional Analysis of the PREP1 Interactor: p160 Myb Binding Protein 1. Doctor of Philosophy (PhD) thesis The Open University.

Occhi, Simona (2010). The Fat Gene Cooperates With the Hippo Pathway to Prevent Neuronal Degeneration. Doctor of Philosophy (PhD) thesis The Open University.

Sauer, Aisha Vanessa (2010). Immunological and non-immunological defects in adenosine deaminase deficiency and their correction by different therapeutic approaches. Doctor of Philosophy (PhD) thesis The Open University.

Vavassori, Stefano (2010). Structural and functional characterization of human ERp44: a closer look at a member of PDI family regulating protein quality control in the early secretory pathway. Doctor of Philosophy (PhD) thesis The Open University.

2009To Top

Bolis, Annalisa (2009). Role of Mtmr2 phosphatase as a regulator of kif13B, Dlg1 and Sec8 mediated myelination in Schwann cells. Doctor of Philosophy (PhD) thesis The Open University.

Cassina, Laura (2009). The mitochondrial metalloproteases of the inner membrane, paraplegin and AFG3L2, regulate mitochondrial morphology : generation of cellular models and analysis of mitochondrial dynamics. Doctor of Philosophy (PhD) thesis The Open University.

Cassol, Edana (2009). Mononuclear phagocyte activation and its role in HIV-1 pathogenesis. Doctor of Philosophy (PhD) thesis The Open University.

Esposito, Marianna (2009). Immune regulation in experimental autoimmune encephalomyelitis : the role of regulatory T cells. Doctor of Philosophy (PhD) thesis The Open University.

Passerini, Laura (2009). The role of FOXP3 in regulatory and effector function of CD4⁺ T cells isolated from patients with FOXP3 mutations. Doctor of Philosophy (PhD) thesis The Open University.

Penzo, Marianna (2009). HMGB1 chemotactic responses differentially depend on IKKα and IKKβ to drive two NF-kB pathways. Doctor of Philosophy (PhD) thesis The Open University.

Pusterla, Tobias (2009). HMGB1 and its role in breast cancer progression and malignancy. Doctor of Philosophy (PhD) thesis The Open University.

Tinelli, Elisa (2009). Unfolded protein response in P0-S63del mice : a model of CMT1B neuropathy. Doctor of Philosophy (PhD) thesis The Open University.

Visigalli, Ilaria (2009). Ex Vivo Gene Therapy Approaches for the Treatment of Globoid Cell Leukodystrophy. Doctor of Philosophy (PhD) thesis The Open University.

2008To Top

Canderan, Glenda (2008). Definition of an in vitro strategy to efficiently induce and propagate T cells suitable for the characterization of non-small cell lung cancer (NSCLC) antigenoma. Doctor of Philosophy (PhD) thesis The Open University.

Cattoglio, Claudia (2008). Target Site Selection of Retroviral Vectors in the Human Genome: Viral and Genomic Determinants of Non-Random Integration Patterns in Hematopoietic Cells. Doctor of Philosophy (PhD) thesis The Open University.

Gualdoni, Sara (2008). Characterization of the Role of Rac3 in Neuronal Function. Doctor of Philosophy (PhD) thesis The Open University.

Hess Michelini, Rodrigo (2008). Non-myeloablative allotransplantation combined with tumour-specific vaccination for the treatment of prostate cancer. Doctor of Philosophy (PhD) thesis The Open University.

Malengo, Gabriele (2008). Dynamics and oligomerization of urokinase plasminogen activator receptor (uPAR) : a GPI-anchored receptor studied by fluorescence micro-spectroscopy. Doctor of Philosophy (PhD) thesis The Open University.

Masciarelli, Silvia (2008). Molecular physiology of plasma cell differentiation. Doctor of Philosophy (PhD) thesis The Open University.

Mollica, Luca (2008). Structure and Dynamics of High Mobility Group Box Protein 1 (HMGB1) Complexed With Inhibitors of Its Proinflammatory Activity: A Combined Nuclear Magnetic Resonance and Computational Chemistry Approach. Doctor of Philosophy (PhD) thesis The Open University.

Riba, Michela (2008). Mitochip, microarray of human mitochondrial protein genes, development and applications. Doctor of Philosophy (PhD) thesis The Open University.

2007To Top

Cassani, Barbara (2007). Molecular mechanisms of immune deficiency in adenosine deaminase (ADA)-deficient SCID patients: implications for stem cell gene therapy. Doctor of Philosophy (PhD) thesis The Open University.

Colombo, Elena (2007). The aristaless-related homeobox gene, ARX, during the forebrain development : its crucial role in the organization and differentiation of the ventral telencephalon. Doctor of Philosophy (PhD) thesis The Open University.

Ferrai, Carmelo (2007). Transcription regulation through chromatin structure and nuclear compartmentalization. Doctor of Philosophy (PhD) thesis The Open University.

Latorre, Elisa (2007). Multidrug resistance proteins (MRP) transport the cytokine/nuclear protein High Mobility Group Box 1 (HMGB1) across membranes. Doctor of Philosophy (PhD) thesis The Open University.

Marturano, Jill (2007). Tumor antigen processing and presentation on MHC Class II molecules for CD4⁺ T cell recognition in health and disease. Doctor of Philosophy (PhD) thesis The Open University.

Orsi, Andrea (2007). Role of covalent modifications in PrP folding and maturation : biological and pathological implications. Doctor of Philosophy (PhD) thesis The Open University.

Sironi, Cristina Lynne (2007). Functional and biochemical characterization of EFA6As, a protein involved in cytoskeletal remodeling in neuronal cells. Doctor of Philosophy (PhD) thesis The Open University.

Trisciuoglio, Lisa (2007). The relation between HMGB1 immobilization and other nuclear processes during apoptosis. Doctor of Philosophy (PhD) thesis The Open University.

Xynos, Alexandros (2007). Genetic analysis and functional characterization of factors affecting BM-derived myogenesis. Doctor of Philosophy (PhD) thesis The Open University.

Za, Lorena (2007). Study of the role of GIT1 complex in cytoskeletal remodelling, adhesion and membrane traffic during cell motility. Doctor of Philosophy (PhD) thesis The Open University.

2006To Top

Baruah, Paramita (2006). Innate opsonins : modulating perception of cell death and inflammation. Doctor of Philosophy (PhD) thesis The Open University.

Biressi, Stefano Augusto Maria (2006). The molecular basis of skeletal myoblast diversification : gene expression analysis of purified embryonic and foetal myoblasts from Myf5GFP-P mice. Doctor of Philosophy (PhD) thesis The Open University.

Bonanomi, Dario (2006). Molecular mechanisms of protein sorting in the synaptic vesicle life cycle. Doctor of Philosophy (PhD) thesis The Open University.

Giordano, Tiziana (2006). Insulin and chromogranin B secretory granules in β cell lines under physiological and stress conditions. Doctor of Philosophy (PhD) thesis The Open University.

Mortellaro, Alessandra R (2006). Study of gene therapy efficacy in adenosine deaminase-deficient animal model. Doctor of Philosophy (PhD) thesis The Open University.

Nodari, Alessandro (2006). Role of laminin receptors in peripheral nervous system myelination. Doctor of Philosophy (PhD) thesis The Open University.

Piccirillo, Rosanna (2006). Sorting and activation of ocular albinism type 1 protein, AG protein-coupled receptor of intracellular organelles. Doctor of Philosophy (PhD) thesis The Open University.

Santoni de Sio, Francesca Romana (2006). Critical parameters and molecular analysis of lentiviral vector-mediated gene transfer into human haematopoietic stem cells. Doctor of Philosophy (PhD) thesis The Open University.

Trifari, Sara (2006). The role of Wiskott-Aldrich Syndrome protein in activation and function of human T cells. Doctor of Philosophy (PhD) thesis The Open University.

2005To Top

Abenavoli, Alessandra (2005). Studies on single synapse release probability. Doctor of Philosophy (PhD) thesis The Open University.

Andolfo, Annapaola (2005). Study on uPAR interactions : from cleavage to dimerization. Doctor of Philosophy (PhD) thesis The Open University.

Dumitriu, Ingrid Elena (2005). A role for extracellular HMGB1 in regulation of dendritic cell maturation and function. The Open University.

Muzio, Luca (2005). The role of EMX genes during the development of the mammalian cerebral cortex. Doctor of Philosophy (PhD) thesis The Open University.

Rossetti, Grazisa (2005). Functional characterization of mammalian COP9 signalosome and its downstream effector huCOP1. Doctor of Philosophy (PhD) thesis The Open University.

Santoro, Fabio (2005). Molecular characterization of the cellular receptor for human herpesvirus 6 and the viral glycoproteins involved in receptor recognition. Doctor of Philosophy (PhD) thesis The Open University.

2004To Top

Bonaldi, Tiziana (2004). Mechanistical studies of two functions of HMGB1 protein : facilitation of nucleosome sliding and translocation from the nucleus to the extracellular medium. Doctor of Philosophy (PhD) thesis The Open University.

Faedo, Andrea (2004). Identification and characterization of genes preferentially expressed in embryonic telencephalon and CNS stem cells. Doctor of Philosophy (PhD) thesis The Open University.

Ferretti, Elizabetta (2004). Molecular studies towards understanding the role of Prep1 (Pbx Regulation Protein 1) in segmental expression of Hox proteins in the vertebrate hindbrain. Doctor of Philosophy (PhD) thesis The Open University.

Sessa, Luca (2004). Epigenetic control of human HOX clusters. Doctor of Philosophy (PhD) thesis The Open University.

Zarovni, Natasa (2004). Targeted delivery of TNF-[alpha] to tumor vessels : gene therapy approach. The Open University.

2003To Top

Albertinazzi, Chiara (2003). Functional analysis of RAC1B during neuronal development. Doctor of Philosophy (PhD) thesis The Open University.

Barsacchi, Rico (2003). Role of nitric oxide in the regulation of tumor necrosis factor-alpha signalling. Doctor of Philosophy (PhD) thesis The Open University.

De Filippis, Lidia (2003). The Phospholipase C Signalling System: Study of the role of the G₀ protein and identification of a novel variant of Phospholipase C β4. Doctor of Philosophy (PhD) thesis The Open University.

Kilstrup-Nielsen, Charlotte (2003). Molecular mechanisms underlying the regulation of PBX subcellular localization. Doctor of Philosophy (PhD) thesis The Open University.

Lotti, Francesco (2003). Transcriptional targeting of lentiviral vectors to the erythroblastic progeny of hematopoietic stem cells. Doctor of Philosophy (PhD) thesis The Open University.

Paolucci, Clara (2003). Role of nitric oxide in the maturation process of human dendritic cells. Doctor of Philosophy (PhD) thesis The Open University.

2002To Top

Borgonovo, Barbara (2002). Characterisation of a novel Ca²⁺-dependent exocytosis. The Open University.

Caronia, Giuliana (2002). An I47L substitution in the HOXD13 homeodomain causes a novel human limb malformation by producing a selective loss of function. Doctor of Philosophy (PhD) thesis The Open University.

Scaffidi, Paola (2002). Study of the chromatin binding properties of the high mobility group 1 protein (HMGB1) in living and dead cells. Doctor of Philosophy (PhD) thesis The Open University.

Sofia, Francesca (2002). Emx1 null mutant mouse phenotype: potential implications for human epilepsy. Doctor of Philosophy (PhD) thesis The Open University.

Taveggia, Carla (2002). Distal transcriptional activators of the myelin basic protein gene in oligodendrocytes and Schwann cells. Doctor of Philosophy (PhD) thesis The Open University.

2001To Top

Corradi, Anna (2001). Ebf2, a new regulator of neuronal differentiation: from gene identification to analysis of the Ebf2 -/- mouse. Doctor of Philosophy (PhD) thesis The Open University.

Furlan, Robert (2001). Development of herpesvirus-based vectors for the treatment of central nervous system autoimmune diseases. Doctor of Philosophy (PhD) thesis The Open University.

2000To Top

Bertocchini, Federica (2000). Expression and functional analysis of murine ryanodine receptor type 3. Doctor of Philosophy (PhD) thesis The Open University.

Cattelino, Anna (2000). A "cell-free" system to study regulation of focal adhesions and of the connected actin cytoskeleton. Doctor of Philosophy (PhD) thesis The Open University.

Moro, Monica (2000). Manipulation of anti tumour immune response by tumour targeting with soluble immuno-modulatory molecules. Doctor of Philosophy (PhD) thesis The Open University.

Pagani, Massimiliano (2000). Redox control in the exocytic pathway. The Open University.

Ronfani, Lorenza (2000). Cloning and knock-out of the mouse gene coding for the high mobility group 2 protein (HMG2). Doctor of Philosophy (PhD) thesis The Open University.

Rovere Querini, Patrizia (2000). Clearance of dying cells by antigen presenting and scavenger phagocytes : implications for autoimmunity and tolerance. Doctor of Philosophy (PhD) thesis The Open University.

Santoro, Massimo M (2000). The binding of 14-3-3 proteins to the Ron receptor is required for its biological activity. The Open University.

Vujanac, Milos (2000). Characterization of Inactive and Stress-Induced Active Forms of the Transcription Factor HSF1: An analysis at the cellular level. Doctor of Philosophy (PhD) thesis The Open University.

1999To Top

Di Rocco, Giuliana (1999). Functional characterisation of a HOX/PBX transcriptional complex. Doctor of Philosophy (PhD) thesis The Open University.

Passini, Nadia (1999). Molecular mechanisms of T helper 1 and T helper 2 cell development: differential signalling in response to Interleukin-12. Doctor of Philosophy (PhD) thesis The Open University.

1998To Top

Pontiggia, Andrea (1998). Characterization and mutations in the human sex determining factor SRY. Doctor of Philosophy (PhD) thesis The Open University.

Sturniolo, Tiziana Concetta (1998). Systematic characterisation of HLA class II ligand binding specificity by quantitative matrices. Doctor of Philosophy (PhD) thesis The Open University.

1997To Top

Brunelli, Silvia (1997). EMX2 and the development of the cerebral cortex : mutations linked to human congenital disorders and analysis of transgenic mice. Doctor of Philosophy (PhD) thesis The Open University.

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