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Psoma, Sotiria
(2024).
URL: https://endocrine-diabetes.org/
Abstract
Biosensors have a great potential to revolutionise healthcare and make disease diagnosis and monitoring not only easier with real-time capabilities but also affordable without the use of expensive medical equipment and highly specialised medical staff. It is well known that for nearly 50 years, the glucose biosensor has mainly been used for diabetes management. The blood glucose measurements has been used to determine the administrating critical insulin dosage, however this is an indirect method with a number of withdrawals such as the insulin sensitivity issue. Traditional lab-based analytical techniques for insulin measurement are expensive and time-consuming and lack a real-time monitoring capability. As a result a direct real-time insulin measurement using a biosensor platform will optimise and personalise the insulin dosage and improve the diabetes management. Currently, a relative small number of insulin biosensors have been published using nanomaterials such aptamer-based, molecularly imprinted polymer (MIP)-based, quantum dots, or label-free and other types are among the latest developments in this multidisciplinary field with challenges and innovations. The wearable device will offer a more accurate estimation of the required insulin dosage, and contribute towards a reliable artificial pancreas, which is the gold standard in diabetes management and personalised medicine.