Rapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment

Fossey, John S.; Anslyn, Eric V.; Brittain, William D. G.; Bull, Steven D.; Chapin, Brette M.; Le Duff, Cécile S.; James, Tony D.; Lees, Glenn; Lim, Stephanie; Lloyd, Jennifer A. C.; Manville, Charles V.; Payne, Daniel T. and Roper, Kimberley A. (2017). Rapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment. Journal of Chemical Education, 94(1) pp. 79–84.

DOI: https://doi.org/10.1021/acs.jchemed.6b00355

Abstract

An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the determination of enantiomeric excess by 1H NMR spectroscopy. This report describes the delivery of the experiment to a cohort of students, and as a result of feedback from those involved, an optimized protocol is presented. Particular care has been taken to facilitate ready adoption in other institutions by providing comprehensive teaching support materials as well as technical guidance for supporting the experiment.

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