Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives

Payne, Daniel T.; Zhao, Yiming and Fossey, John S. (2017). Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives. Scientific Reports, 7, article no. 1720.

DOI: https://doi.org/10.1038/s41598-017-01950-7

Abstract

Methodology has been developed for the synthesis of 3-propanaldehydes through a five-step process in 11–67% yield from aldehydes. Aldehydes were reacted with Meldrum’s acid through a Knoevenagel condensation to give materials that upon reduction with sodium borohydride and subsequent hydrolysis decarboxylation generated the corresponding 3-propanoic acid derivatives. The -propanoic acid derivatives were reduced to give 3-propanol derivatives, which were readily oxidised to target 3-propanal derivatives.

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