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Cerutti, Camilla and Romero, Ignacio A.
(2022).
DOI: https://doi.org/10.1007/978-1-0716-2289-6_19
Abstract
Adhesion between leukocytes and brain endothelial cells, which line cerebral blood vessels, is a key event in both physiological and pathological conditions such as neuroinflammatory diseases. Leukocyte recruitment from blood into tissues is described as a multistep process involving leukocyte rolling on endothelial cells, adhesion, crawling, and diapedesis under hemodynamic shear stress. In neuroinflammatory conditions, there is an increase in leukocyte adhesion to the brain endothelial cells, activated by proinflammatory molecules such as cytokines. Here, we describe an in vitro technique to study the interaction between human leukocytes with human brain endothelial cells under shear stress mimicking the blood flow in vivo, coupled to live-cell imaging.
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- Item ORO ID
- 84201
- Item Type
- Book Section
- ISBN
- 1-07-162289-7, 978-1-07-162289-6
- ISSN
- 1064-3745
- Keywords
- cytokines; leukocytes; brain endothelial cells; cell adhesion; shear stress; live-cell imaging; neuroinflammation; CNS
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Copyright Holders
- © 2022 The Author(s)
- Related URLs
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- https://doi.org/10.1007/978-1-0716-2289-...(Publication)
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- ORO Import