Synthesis of asymmetrically substituted cyclen-based ligands for the controlled sensitisation of lanthanides

Bruce, James I. and Borbas, K. Eszter (2007). Synthesis of asymmetrically substituted cyclen-based ligands for the controlled sensitisation of lanthanides. Organic and biomolecular chemistry, 5(14) pp. 2274–2282.

DOI: https://doi.org/10.1039/b705757a

Abstract

A series of unsymmetrical cyclen-based ligands incorporating an antenna and a quencher have been prepared for the complexation of the visible- (Eu, Tb) and near IR-emitting (Nd, Yb) lanthanides. Eu and Tb were sensitised with coumarin 2, and Nd and Yb with rhodamine. Both antennae were paired with nucleoside (uridine and adenosine) quenchers. The interaction between the quencher and the antenna can be regulated by the addition of the complementary base or DNA to the complexes, resulting in changes in the lanthanide luminescence intensity and lifetime.

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