HAR1: an insight into lncRNA genetic evolution

Waters, Ella; Pucci, Perla; Hirst, Mark; Chapman, Simon; Wang, Yuzhuo; Crea, Francesco and Heath, Christopher (2021). HAR1: an insight into lncRNA genetic evolution. Epigenomics, 13(22) pp. 1831–1843.

DOI: https://doi.org/10.2217/epi-2021-0069

Abstract

Long noncoding RNAs (lncRNAs) have a wide range of functions in health and disease, but many remain uncharacterized because of their complex expression patterns and structures. The genetic loci encoding lncRNAs can be subject to accelerated evolutionary changes within the human lineage. HAR1 is a region that has a significantly altered sequence compared to other primates and is a component of two overlapping lncRNA loci, HAR1A and HAR1B. Although the functions of these lncRNAs are unknown, they have been associated with neurological disorders and cancer. Here, we explore the current state of understanding of evolution in human lncRNA genes, using the HAR1 locus as the case study.

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About

• Item ORO ID
• 79701
• Item Type
• Journal Item
• ISSN
• 1750-192X
• Project Funding Details

• Funded Project Name	Project ID	Funding Body
  Not Set	Not Set	The Open University (OU)

• Keywords
• DNA conservation; genetic evolution; HAR1; lncRNAs; molecular structure
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Research Group
• Cancer Research Group
  Neuroscience Research Group
• Copyright Holders
• © 2021 The Authors.
• Depositing User
• Ella Waters