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Waters, Ella; Pucci, Perla; Hirst, Mark; Chapman, Simon; Wang, Yuzhuo; Crea, Francesco and Heath, Christopher
(2021).
DOI: https://doi.org/10.2217/epi-2021-0069
Abstract
Long noncoding RNAs (lncRNAs) have a wide range of functions in health and disease, but many remain uncharacterized because of their complex expression patterns and structures. The genetic loci encoding lncRNAs can be subject to accelerated evolutionary changes within the human lineage. HAR1 is a region that has a significantly altered sequence compared to other primates and is a component of two overlapping lncRNA loci, HAR1A and HAR1B. Although the functions of these lncRNAs are unknown, they have been associated with neurological disorders and cancer. Here, we explore the current state of understanding of evolution in human lncRNA genes, using the HAR1 locus as the case study.
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About
- Item ORO ID
- 79701
- Item Type
- Journal Item
- ISSN
- 1750-192X
- Project Funding Details
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Funded Project Name Project ID Funding Body Not Set Not Set The Open University (OU) - Keywords
- DNA conservation; genetic evolution; HAR1; lncRNAs; molecular structure
- Academic Unit or School
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Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Research Group
-
Cancer Research Group
Neuroscience Research Group - Copyright Holders
- © 2021 The Authors.
- Depositing User
- Ella Waters