Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold

Alcaro, Stefano; Artese, Anna; Iley, James N.; Maccari, Rosanna; Missailidis, Sotiris; Ortuso, Francesco; Ottana, Rosaria; Ragazzon, Patricia and Vigorita, Maria Gabriella (2007). Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold. Bioorganic and Medicinal Chemistry Letters, 17(9) pp. 2509–2514.

DOI: https://doi.org/10.1016/j.bmcl.2007.02.022

Abstract

A series of fluorenone-carboxamide compounds was analyzed with regard to DNA binding properties by UV spectroscopy
and competition dialysis methods. The morpholino derivative 10 provided interesting results in terms of affinity and specificity toward the DNA G-tetraplex structures. Interactions against this target were evaluated by a comparative molecular modeling study in agreement with the experimental data, proposing a model for the rational design of new agents with potent and selective DNA tetraplex binding properties.

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About

• Item ORO ID
• 7446
• Item Type
• Journal Item
• ISSN
• 0960-894X
• Keywords
• DNA tetraplex; drug binding; molecular modeling
• Academic Unit or School
• Other Departments > Other Departments
  Other Departments
  Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Depositing User
• James Iley