Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold

Alcaro, Stefano; Artese, Anna; Iley, James N.; Maccari, Rosanna; Missailidis, Sotiris; Ortuso, Francesco; Ottana, Rosaria; Ragazzon, Patricia and Vigorita, Maria Gabriella (2007). Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold. Bioorganic and Medicinal Chemistry Letters, 17(9) pp. 2509–2514.

DOI: https://doi.org/10.1016/j.bmcl.2007.02.022


A series of fluorenone-carboxamide compounds was analyzed with regard to DNA binding properties by UV spectroscopy
and competition dialysis methods. The morpholino derivative 10 provided interesting results in terms of affinity and specificity toward the DNA G-tetraplex structures. Interactions against this target were evaluated by a comparative molecular modeling study in agreement with the experimental data, proposing a model for the rational design of new agents with potent and selective DNA tetraplex binding properties.

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