Copy the page URI to the clipboard
Vasiliadou, Rafaela and Welham, Kevin
(2017).
DOI: https://doi.org/10.1139/cjc-2017-0279
Abstract
Raloxifene (RLX) is a selective estrogen receptor modulator widely used for the treatment of osteoporosis in post-menopause women. Toxicological in vitro studies suggested the reactivity of RLX through phase I metabolism. Herein, we describe a simple and inexpensive method for monitoring the reactive metabolism and detoxification of RLX by electrochemistry (EC) and mass spectrometry (MS). The phase I metabolite was synthesized electrochemically on a screen-printed electrode (SPE) and subsequently reacted with glutathione (GSH). The resulted GSH-adducts and GSH disulfides were characterized off-line by electrospray ionization (ESI)-MS.
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)
