Terasaki spiral ramps and intracellular diffusion

Huber, Greg and Wilkinson, Michael (2019). Terasaki spiral ramps and intracellular diffusion. Physical Biology, 16(6), article no. 065002.

DOI: https://doi.org/10.1088/1478-3975/ab4080

Abstract

The sheet-like endoplasmic reticulum (ER) of eukaryotic cells has been found to be riddled with spiral dislocations, known as 'Terasaki ramps', in the vicinity of which the doubled bilayer membranes which make up ER sheets can be approximately modeled by helicoids. Here we analyze diffusion on a surface with locally helicoidal topological dislocations, and use the results to argue that the Terasaki ramps facilitate a highly efficient transport of water-soluble molecules within the lumen of the endoplasmic reticulum.

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• Item ORO ID
• 66696
• Item Type
• Journal Item
• ISSN
• 1478-3975
• Keywords
• Terasaki ramps; anomalous diffusion; cell biology; cytoplasmic diffusion; diffusion; endoplasmic reticulum; organelles
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Mathematics and Statistics
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Copyright Holders
• © 2019 IOP Publishing Ltd
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• Jisc Publications-Router
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