The rheology of human blood and blood cellular components in suspension measured with a modified Weissenberg rheogoniometer

King, Robert G (1984). The rheology of human blood and blood cellular components in suspension measured with a modified Weissenberg rheogoniometer. PhD thesis The Open University.

DOI: https://doi.org/10.21954/ou.ro.000100f1

Abstract

The development of the Weissenberg Rheogoniometer is described, together with details of the modifications that were required to adapt it for hemorheological studies.

The rheological parameters, viscosity and elasticity of whole blood from healthy human donors, prepared in concentrations of red cells from 10. to 95 percent, were measured in steady, oscillatory and pulsatile flow. The viscosity and elasticity of red cells resuspended in buffer solution at similar concentrations are also reported. The changing rheological properties of the clotting process of non-anticoagulated human blood have been studied with time.

Preparations of red cells and white cells in abnormal states (in sickle cell disease and leukemia) have been studied and the rheological data reported.

Surface rheological investigations are also made of preparations of blood proteins such as fibringen, albumin and spectrin/actin derived from the red cell membrane. These materials are deployed both at air-fluid and fluid-fluid interfaces. The effect of the addition of such materials as coagulating and anticoagulating agents to these preparations are also studied.

The results of these investigations serve to establish the mechanism regulating the viscoelastic behavior of blood in health and to elucidate the pathophysiological changes in blood rheology in disease.

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