Stretch activation in muscle: a Ca²⁺ independent mechanism?

De Nicola, Gian Felice (2008). Stretch activation in muscle: a Ca²⁺ independent mechanism? PhD thesis The Open University.

DOI: https://doi.org/10.21954/ou.ro.0000fa62

Abstract

The aim of this thesis has been the understanding at the molecular level of stretch activation in muscles. Stretch activation is a feature common to all types of muscle. Such a mechanism is particularly important in cardiac muscles in vertebrates and in indirect flight muscles in insects. Here, the three-dimensional structure of Lethocerus troponin C isoform (F1), recently discovered to be crucial in regulating stretch-activated contraction, is presented. The interactions between F1 and the other subunits of the Lethocerus troponin trimer are also analyzed. Finally a model for stretch activation in muscle, based on the experimental data produced during this thesis, is proposed.

Viewing alternatives

Metrics

Item Actions

Export

You can export this page using these formats Digital Object Identifier - DOI