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Kilburn, John Paul; Lau, Jesper and Jones, Raymond C. F.
(2002).
DOI: https://doi.org/10.1016/S0040-4039(02)00525-7
Abstract
A novel and facile strategy for synthesis of substituted 2-amino-1,3,4-thiadiazines on solid support is described. Resin bound isothiocyanate prepared from an immobilised primary amine and di-(2-pyridyl)thionocarbonate was reacted with hydrazine hydrate to form the intermediate thiosemicarbazide. Further reaction with a range of alpha-bromoketones followed by mild acidic cleavage from the solid support released the substituted 2-amino-1,3,4-thiadiazines in respectable yields and excellent purity. (C) 2002 Elsevier Science Ltd. All rights reserved.
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About
- Item ORO ID
- 6169
- Item Type
- Journal Item
- ISSN
- 0040-4039
- Keywords
- Chemistry
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Depositing User
- Astrid Peterkin