The Role Of p14ARF In Familial And Sporadic Melanoma

Mistry, Sushilaben Harkisandas (2004). The Role Of p14ARF In Familial And Sporadic Melanoma. PhD thesis University of Leeds.

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Item ORO ID
59023
Item Type
PhD Thesis
Extra Information
The author was the first to: comprehensively screen for deletions on chromosome 9p in melanoma families and in sporadic melanomas (at a time when it was difficult for detect deletions and loss of heterozygosity, LOH); to identify p14ARF [CDKN2A-ARF gene (exon 1β)] as a tumour suppressor gene; identify the MTAP to KIAA1 gene region as important in melanoma aetiology and a candidate locus for the location of a tumour suppressor gene; and contributed to being the first to identify that introns are important in disease with the detection of a splicing variant (IVS2-105) in melanoma families.
Keywords
chromosomes; melanoma; tumours; cancer
Academic Unit or School
Other Departments
Research Group
Cancer Research Group
Copyright Holders
Depositing User
Sushila Rigas

CORE (COnnecting REpositories)