The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study

Frank, Bernd; Rigas, Sushila H.; Bermejo, Justo Lorenzo; Wiestler, Miriam; Wagner, Kerstin; Hemminki, Kari; Reed, Malcolm W.; Sutter, Christian; Wappenschmidt, Barbara; Balasubramanian, Sabapathy P.; Meindl, Alfons; Kiechle, Marion; Bugert, Peter; Schmutzler, Rita K.; Bartram, Claus R.; Justenhoven, Christina; Ko, Yon-Dschun; Brüning, Thomas; Brauch, Hiltrud; Hamann, Ute; Pharoah, Paul P. D.; Dunning, Alison M.; Pooley, Karen A.; Easton, Douglas F.; Cox, Angela and Burwinkel, Barbara (2008). The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study. Breast Cancer Research and Treatment, 111(1) pp. 139–144.

DOI: https://doi.org/10.1007/s10549-007-9752-z

Abstract

A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.

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