Communication: Site-selective bond excision of adenine upon electron transfer

Cunha, T.; Mendes, M.; Ferreira da Silva, F.; Eden, S.; García, G. and Limão-Vieira, P. (2018). Communication: Site-selective bond excision of adenine upon electron transfer. Journal of Chemical Physics, 148(2), article no. 021101.

DOI: https://doi.org/10.1063/1.5018401

Abstract

This work demonstrates that selective excision of hydrogen atoms at a particular site of the DNA base adenine can be achieved in collisions with electronegative atoms by controlling the impact energy. The result is based on analysing the time-of-flight mass spectra yields of potassium collisions with a series of labeled adenine derivatives. The production of dehydrogenated parent anions is consistent with neutral H loss either from selective breaking of C–H or N–H bonds. These unprecedented results open up a new methodology in charge transfer collisions that can initiate selective reactivity as a key process in chemical reactions that are dominant in different areas of science and technology.

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