Facile synthesis of novel hybrid POSS biomolecules via “Click” reactions

El Aziz, Youssef; Mehrban, Nazia; Taylor, Peter G.; Birchall, Martin A.; Bowen, James; Bassindale, Alan R.; Pitak, Mateusz B. and Coles, Simon J. (2017). Facile synthesis of novel hybrid POSS biomolecules via “Click” reactions. RSC Advances, 7(59) pp. 37474–37477.

DOI: https://doi.org/10.1039/C7RA07915J

Abstract

A novel alkyne-terminated cubic-octameric POSS was synthesised in high yield (82–90%). The X-ray crystal structure revealed intra- and intermolecular hydrogen bonding between the amide groups of the arms. Hybrid biomaterials were synthesised in nearly quantitative yields via a click reaction with (i) azido-N-Fmoc- norleucine and (ii) 3'-azido-3'-deoxythymidine.

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