Electrospray synthesis of PLGA TIPS microspheres

Malik, S. A.; Ng, W. H.; Bowen, J.; Tang, J.; Gomez, A.; Kenyon, A. J. and Day, R. M. (2015). Electrospray synthesis of PLGA TIPS microspheres. In: European Aerosol Conference, 6-11 Sep 2015, Milan, Italy.

URL: http://www.eac2015.it/

Abstract

We successfully demonstrate the synthesis of polymer microspheres using a single electrospray source, and show their physical characterisation. Electrospray has proven to be a versatile method to manufacture particles, giving tight control over size with quasi-monodisperse size distributions. It is a liquid atomisation technique that generates a monodisperse population of highly charged liquid droplets over a broad size range (nanometres to tens of microns). The droplets contain liquid precursors for the in-flight synthesis of particles, and control over the trajectory of these droplets can be precisely manipulated with the use of electric fields to drive them to a grounded substrate. This study reports a method to synthesize poly(lactic-co-glycolic) acid (PLGA) microspheres using the electrospray and thermally induced phase separation (TIPS) techniques, followed by subsequent freeze-drying, for particle production. These microspheres are of interest as vehicles for controlled drug release systems.

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