Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid

Maki, Takakuni; Okamoto, Yoko; Carare, Roxana O.; Hase, Yoshiki; Hattori, Yorito; Hawkes, Cheryl A.; Saito, Satoshi; Yamamoto, Yumi; Terasaki, Yasukazu; Ishibashi-Ueda, Hatsue; Taguchi, Akihiko; Takahashi, Ryosuke; Miyakawa, Taihei; Kalaria, Raj N.; Lo, Eng H.; Arai, Ken and Ihara, Masafumi (2014). Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid. Annals of Clinical and Translational Neurology, 1(8) pp. 519–533.

DOI: https://doi.org/10.1002/acn3.79

Abstract

The predominant action of cilostazol on Aβ metabolism is likely to facilitate Aβ clearance due to the sustained cerebrovascular function in vivo. Our findings mechanistically demonstrate that cilostazol is a promising therapeutic approach for AD and CAA.

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