Targeting prostate cancer stem cells.

Crea, Francesco; Mathews, Lesley A.; Farrar, William L. and Hurt, Elaine M. (2009). Targeting prostate cancer stem cells. Anti-cancer agents in medicinal chemistry, 9(10) pp. 1105–1113.

DOI: https://doi.org/10.2174/187152009789735053

Abstract

Cancer stem cells are the sub-population of cells present within tumors responsible for tumorigenesis. These cells have unique biological properties including self-renewal and the ability to differentiate. Furthermore, it is thought that these cells are more resistant to conventional chemotherapy and, as a result, are responsible for patient relapse. We will discuss the identification of prostate cancer stem cells, their unique properties and how these cells may be targeted for more efficacious therapies.

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