EZH2 and cancer stem cells: fact or fiction?

Crea, Francesco (2011). EZH2 and cancer stem cells: fact or fiction? Epigenomics, 3(2) pp. 127–128.

DOI: https://doi.org/10.2217/EPI.11.4

Abstract

Several recent publications have shed new light on the role of epigenetic modifications in cancer stem cell (CSC) biology. Among other epigenetic players, polycomb group genes appear to be particularly attractive. Indeed, they are emerging as CSC-specific markers, as well as potential targets for cancer therapy. However, before these discoveries can be applied to the clinical setting, the specific role of polycomb group genes in CSC tumorigenic activity should be explained further.

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