Genome-epigenome interactions: the Polycomb paradox.

Crea, Francesco and Fornaro, Lorenzo (2014). Genome-epigenome interactions: the Polycomb paradox. Epigenomics, 6(1) pp. 5–7.

DOI: https://doi.org/10.2217/epi.13.86

Abstract

The last two decades of molecular biology research have revealed that cancer is not simply a genetic disease. Epigenetic alterations, ranging from DNA methylation to histone post-translational modifications, deeply interact with gene mutations, amplifications and deletions. It has been long debated whether epigenetic deregulations precede the appearance of somatic mutations, or if they are simply an "epi-phenomenon" of genetic instability.

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