Embryonic stem cell pathways and chemotherapy response: an unexplored route.

Duhagon, M. A.; Crea, F.; Danesi, R. and Farrar, W. L. (2013). Embryonic stem cell pathways and chemotherapy response: an unexplored route. Annals of Oncology, 24(2) pp. 558–559.

DOI: https://doi.org/10.1093/annonc/mds610

Abstract

Cancer stem cells (CSCs) are a subpopulation of cancer cells with long-lasting tumorigenic potential. CSCs share with embryonic stem cells (ESCs) an unlimited self-renewal potential and a notable phenotypic plasticity which are sustained by common gene expression programs. CSCs have been associated with drug resistance and relapse in most cancer types. Although CSC-specific pathways were shown to mediate chemoresistance in several preclinical studies, methodological and conceptual complexity has obstructed the examination of this hypothesis in the clinical setting.

Viewing alternatives

Metrics

Item Actions

Export

You can export this page using these formats Digital Object Identifier - DOI