Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells

Chiacchia, M.; Cerutti, C.; Gromnicova, R.; Rietdorf, K.; Romero, I.A. and Bradshaw, D. (2015). Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells. Journal of Materials Chemistry B, 3(46) pp. 9053–9059.

DOI: https://doi.org/10.1039/C5TB01814E

Abstract

Herein, we report the synthesis and characterization of nanospheres of a biodegradable zinc-imidazolate polymers (ZIPs) as a proof-of-concept delivery vehicle into human brain endothelial cells, the main component of the blood-brain barrier (BBB). The ZIP particles can readily encapsulate functional molecules such as fluorophores and inorganic nanoparticles at the point of synthesis producing stable colloidal dispersions. Our results show that these biodegradable particles are not cytotoxic, and are able to penetrate and release cargo species to human brain capillary endothelial cells in vitro thus exhibiting significant potential as a novel platform for brain targeting treatments.

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About

• Item ORO ID
• 45725
• Item Type
• Journal Item
• ISSN
• 2050-750X
• Project Funding Details

• Funded Project Name	Project ID	Funding Body
  Not Set	ERC-2010-StG-258613-BIOMOF	European Research Council

• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Copyright Holders
• © 2015 Royal Society of Chemistry
• Depositing User
• Radka Gromnicova