The INTERPRET-DD study of diabetes and depression: a protocol

Lloyd, C. E.; Sartorius, N.; Cimino, L. C.; Alvarez, A.; Guinzbourg de Braude, M.; Rabbani, G.; Uddin Ahmed, H.; Papelbaum, M.; Regina de Freitas, S.; Ji, L.; Yu, X.; Gaebel, W.; Mussig, K.; Chaturvedi, S. K.; Srikanta, S. S.; Burti, L.; Bulgari, V.; Musau, A.; Ndete, D.; Heinze, G.; Romo Nava, F.; Taj, R.; Khan, A.; Kokoszka, A.; Papasz-Siemieniuk, A.; Starostina, E. G.; Bobrov, A. E.; Lecic-Tosevski, D.; Lalic, N. M.; Udomratn, P.; Tangwongchai, S.; Bahendeka, S.; Basangwa, D. and Mankovsky, B. (2015). The INTERPRET-DD study of diabetes and depression: a protocol. Diabetic Medicine, 32(7) pp. 925–934.




Aim People with diabetes are at an increased risk of developing depression and other psychological disorders. However little is known about the prevalence, correlates, or care pathways in countries other than the UK and the US. A new study, the International Prevalence and Treatment of Diabetes and Depression (INTERPRET-DD) Study aims to address this dearth of knowledge and identify optimal pathways to care across the globe.

Method INTERPRET-DD is a two-year longitudinal study, taking place in 16 countries’ diabetes out-patients facilities, investigating the recognition and management of depressive disorders in people with type 2 diabetes. Clinical interviews are used to diagnose depression, with clinical and other data obtained from medical records and through patient interviews. Pathways to care and the impact of treatment for previously unrecognised depression on clinical outcomes and emotional well-being are being investigated.

Results Initial evidence indicates a range of pathways to care exist, with few of these based on available recommendations for treatment. Pilot data indicates that the instruments we are using to measure both symptoms and clinical diagnosis of depression are acceptable in our study population and easy to use.

Conclusions Our study will increase the understanding of the impact of co-morbid diabetes and depression and identify the most appropriate (country specific) pathways via which patients receive their care. It addresses an important public health problem and lead to recommendations for best practice relevant to the different participating centres with regard to the identification and treatment of people with co-morbid diabetes and depression.

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