Surface modification of silicon substituted apatite

Jiang, Peih-Jeng; Mendes, Paula M.; Bowen, James and Grover, Liam M. (2009). Surface modification of silicon substituted apatite. In: 8th Annual Conference of the UK Society for Biomaterials, 2-3 Jul 2009, Newtownabbey, UK.



Since the pioneering experiments of Carlisle, silicon has been proposed to play a key role in the process of biomineralisation. Consequently, there has been a significant body of research that seeks to incorporate silicon substitutions into the apatite lattice. Recent work has also seen the modification of unsubstituted apatite to incorporate functional groups onto the surface of apatite crystals in order to attach specific enzymes, drugs, or other therapeutic biomolecules. In this study, we have modified the surface of apatite nanocrystals with thiol functional groups. The silicon substituted HA with thiol were analyzed using X-ray diffraction, Fourier Transform Infrared spectroscopy and X-ray photoelectron spectroscopy.

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