Monitoring mineralisation in hydrogels at the engineered hard/soft tissue interface

Koburger, Susanne; Bannerman, Alistair; Grover, Liam M; Müller, Frank A and Bowen, James (2013). Monitoring mineralisation in hydrogels at the engineered hard/soft tissue interface. In: 12th Annual Conference of the UK Society for Biomaterials, 24-25 Jul 2013, Birmingham, UK.

URL: https://www.academia.edu/9853023/Monitoring_minera...

Abstract

In vivo, the interfaces between musculoskeletal tissues display complex matrix heterogeneity, evolved to counter the effects of force transmission through tissues with different mechanical properties. The osteotendinous junction is comprised of 4 interconnected regions, the tendon/ligament proper, unmineralised fibrocartilage, mineralised fibrocartilage and bone. Mineralisation is a key regulator in determining the compressive modulus across the hard/soft tissue junction and therefore demonstrates an important structure-function relationship at musculoskeletal interfaces. This study describes the use of confocal Raman microscopy (CRM) to visualise mineralisation at the engineered hard/soft tissue interface in vitro. The ability to monitor mineralisation is vital for the development of suitable tissue-engineered solutions for interfacial engineering.

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