Influence of surface-imprinted nanoparticles on trypsin activity

Guerreiro, António; Poma, Alessandro; Karim, Kal; Moczko, Ewa; Takarada, Jessica; de Vargas-Sansalvador, Isabel Perez; Turner, Nicholas; Piletska, Elena; de Magalhães, Cristiana Schmidt; Glazova, Natalia; Serkova, Anastasia; Omelianova, Aleksandra and Piletsky, Sergey (2014). Influence of surface-imprinted nanoparticles on trypsin activity. Advanced Healthcare Materials, 3(9) pp. 1426–1429.

DOI: https://doi.org/10.1002/adhm.201300634

Abstract

[T]he modulation of enzyme activity is presented by protein-imprinted nanoparticles produced using a solid-phase approach. Using trypsin as target, binding of the nanoparticles to the enzyme results in its inhibition or in stabilization, depending on the orientation of the immobilized enzyme used during imprinting.

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