Influence of surface-imprinted nanoparticles on trypsin activity

Guerreiro, António; Poma, Alessandro; Karim, Kal; Moczko, Ewa; Takarada, Jessica; de Vargas-Sansalvador, Isabel Perez; Turner, Nicholas; Piletska, Elena; de Magalhães, Cristiana Schmidt; Glazova, Natalia; Serkova, Anastasia; Omelianova, Aleksandra and Piletsky, Sergey (2014). Influence of surface-imprinted nanoparticles on trypsin activity. Advanced Healthcare Materials, 3(9) pp. 1426–1429.

DOI: https://doi.org/10.1002/adhm.201300634

Abstract

[T]he modulation of enzyme activity is presented by protein-imprinted nanoparticles produced using a solid-phase approach. Using trypsin as target, binding of the nanoparticles to the enzyme results in its inhibition or in stabilization, depending on the orientation of the immobilized enzyme used during imprinting.

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About

• Item ORO ID
• 41991
• Item Type
• Journal Item
• ISSN
• 2192-2659
• Keywords
• enzyme inhibition; molecularly imprinted polymers; molecular recognition; nanoparticles; supramolecular chemistry
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Copyright Holders
• © 2014 Wiley-VCH Verlag
• Depositing User
• Nicholas Turner