Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles

Poma, Alessandro; Brahmbhatt, Heli; Pendergraff, Hannah M.; Watts, Jonathan K. and Turner, Nicholas W. (2015). Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles. Advanced Materials, 27(4) pp. 750–758.

DOI: https://doi.org/10.1002/adma.201404235

Abstract

A strategy to exploit aptamers as recognition elements of molecularly imprinted polymeric nanoparticles (AptaMIP NPs) is presented, via modification of the chemical structure of the DNA. It is demonstrated that the introduction of this modified “aptamer monomer” results in an increase of the affinity of the produced MIP NPs, without altering their physical properties such as size, shape, or dispersibility.

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