Glia selectively approach synapses on thin dendritic spines

Medvedev, Nikolay; Popov, Victor; Henneberger, Christian; Kraev, Igor; Rusakov, Dmitri and Stewart, Michael (2014). Glia selectively approach synapses on thin dendritic spines. Philosophical Transactions of the Royal Society B, 369(1654), article no. 20140047.



This paper examines the relationship between the morphological modality of 189 dendritic spines and the surrounding astroglia using full three dimensional reconstructions of neuropil fragments. An integrative measure of three-dimensional glial coverage confirms that thin spine PSDs are more tightly surrounded by glia. This distinction suggests that diffusion-dependent synapse–glia communication near ‘learning’ synapses (associated with thin spines) could be stronger than that near ‘memory’ synapses (associated with larger spines).

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