Giant nuclei is essential in the cell cycle transition from meiosis to mitosis

Renault, Andrew D.; Zhang, Xiao-Hua; Alphey, Luke S.; Frenz, Lisa M.; Glover, David M.; Saunders, Robert D. C. and Axton, J. Myles (2003). Giant nuclei is essential in the cell cycle transition from meiosis to mitosis. Development, 130(13) pp. 2997–3005.

DOI: https://doi.org/10.1242/10.1242/dev.00501

URL: http://dev.biologists.org/cgi/content/abstract/130...

Abstract

At the transition from meiosis to cleavage mitoses, Drosophila requires the cell cycle regulators encoded by the genes, giant nuclei (gnu), plutonium (plu) and pan gu (png). Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic segregation. We have identified the gnu gene encoding a novel phosphoprotein dephosphorylated by Protein phosphatase 1 at egg activation. Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded during the embryonic cleavage mitoses. Ovarian death and sterility result from gnu gain of function. gnu function requires the activity of pan gu and plu.

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About

• Item ORO ID
• 4035
• Item Type
• Journal Item
• ISSN
• 0950-1991
• Project Funding Details

• Funded Project Name	Project ID	Funding Body
  Not Set	Not Set	UK Medical Research Council (MRC)

• Keywords
• Drosophila melanogaster; Mitosis; DNA replication; Fertilization; Oogenesis; Protein phosphatase 1
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Depositing User
• Robert Saunders