Synthesis by conjugate radical addition of new heterocyclic amino acids with nucleobase side chains

Jones, Raymond C. F.; Berthelot, Didier J.C. and Iley, James N. (2001). Synthesis by conjugate radical addition of new heterocyclic amino acids with nucleobase side chains. Tetrahedron, 57(30) pp. 6539–6555.

DOI: https://doi.org/10.1016/S0040-4020(01)00546-4

Abstract

N-(2-Iodoethyl) and N-(3-iodopropyl)pyrimidines and purines undergo stereoselective conjugate radical addition with an optically active oxazolidinone acceptor to give syn adducts that can be converted into amino acids carrying pyrimidine and purine (nucleobase) side chains.

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