DNA aptamers for in vivo molecular targeted imaging and therapy

Missailidis, Sotiris and Perkins, Alan (2005). DNA aptamers for in vivo molecular targeted imaging and therapy. Tumor Biology, 27(Suppl. 1,) p. 22.

DOI: https://doi.org/10.1159/000090902

URL: http://content.karger.com/ProdukteDB/produkte.asp?...


Introduction: Molecular targeted therapeutics offers high target affinity, specificity and improved therapeutic
potential with reduced side effects. The traditional use of antibodies has presented problems associated with
production, purification, immunogenicity and size, whereas small peptides have reduced affinities and specificities. Aptamers can be generated rapidly against targets, showing a better tumour penetration, rapid uptake and clearance, thus providing effective vehicles for cytotoxic agents.

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