Synthetic chemistry of base-modified DNA and their biological applications

Xu, Yao-Zhong (2002). Synthetic chemistry of base-modified DNA and their biological applications. In: Loakes, David ed. Modified Nulceoside, Synthesis and Applications. Kerala, India: Research Signpost, pp. 1–16.

Abstract

Synthetic chemistry of base-modified DNA has provided a powerful tool for studying DNA-related subjects, in particular for understanding DNA damage and repair. This chapter first introduces basic concepts of DNA synthetic chemistry, and then reviews various approaches to chemical synthesis of base-modified DNA. It also presents the commonly used methods for purification and verification, illustrates applications of the synthetic base-modified oligomers and discusses the potentials of the synthetic chemistry.

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