Systematic assignment of NMR spectra of 5-substituted-4-thiopyrimidine nucleosides

Zhang, Xiaohui; Wang, Jian and Xu, Yao-Zhong (2013). Systematic assignment of NMR spectra of 5-substituted-4-thiopyrimidine nucleosides. Magnetic Resonance in Chemistry, 51(9) pp. 523–529.

DOI: https://doi.org/10.1002/mrc.3980

URL: http://onlinelibrary.wiley.com/doi/10.1002/mrc.398...

Abstract

Unambiguous characterization of 5-substituted-4-thiopyrimidine nucleosides (ribonucleosides and 2'-deoxynucleosides) was performed using NMR spectroscopy. Assignments of all proton and carbon signals of 5-bromo-4-thiouridine and related nucleosides were systematically carried out and firmly established by COSY and HMQC techniques. The NMR data of various 4-thiopyrimidine nucleosides are compared, and the key contributing factors discussed. The approach presented here is applicable to other modified nucleosides and nucleotides, as well as nucleobases.

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