Subcellular Ca²⁺ signals underlying waves and graded responses in HeLa cells

Bootman, Martin D. and Berridge, Michael J. (1996). Subcellular Ca²⁺ signals underlying waves and graded responses in HeLa cells. Current Biology, 6(7) pp. 855–865.

DOI: https://doi.org/10.1016/S0960-9822(02)00609-7

Abstract

The intracellular Ca²⁺ pool in HeLa cells is composed of many functionally discrete units. Upon stimulation, these units produce localized Ca²⁺ signals. The sequential activation and summation of these units results in Ca²⁺ wave propagation and, furthermore, the differential recruitment of these units may underlie the graded amplitude of the intracellular Ca²⁺ signals.

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