Calcium signalling -an overview

Bootman, Martin D.; Collins, Tony J.; Peppiatt, Claire M.; Prothero, Larissa S.; MacKenzie, Lauren; De Smet, Patrick; Travers, Marianne; Tovey, Stephen C.; Seo, Jeong T.; Berridge, Michael J.; Ciccolini, Francesca and Lipp, Peter (2001). Calcium signalling -an overview. Seminars in cell & developmental biology, 12(1) pp. 3–10.

DOI: https://doi.org/10.1006/scdb.2000.0211

Abstract

Calcium (Ca²⁺) is an almost universal intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation. The ability of a simple ion such as Ca²⁺ to play a pivotal role in cell biology results from the facility that cells have to shape Ca²⁺ signals in the dimensions of space, time and amplitude. To generate the variety of observed Ca²⁺ signals, different cell types employ components selected from a Ca²⁺ signalling 'toolkit', which comprizes an array of signalling, homeostatic and sensory mechanisms. By mixing and matching components from the toolkit, cells can obtain Ca²⁺ signals that suit their physiology.

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