Redoxing calcium from the ER

Roderick, H. Llewelyn and Bootman, Martin D. (2005). Redoxing calcium from the ER. Cell, 120(1) pp. 4–5.

DOI: https://doi.org/10.1016/j.cell.2004.12.034

Abstract

Inositol 1,4,5-trisphosphate (InsP₃)-induced calcium release from the endoplasmic reticulum (ER) intracellular calcium store regulates cellular functions from the beginning of life at fertilization until death. In this issue of Cell, Mikoshiba and colleagues describe a novel mode of regulation of the InsP₃ receptor (InsP₃R) governed by ER luminal redox status, calcium, and pH (Higo et al., 2005).

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