New Ca2+ indicator has freedom to express

Roderick, H. Llewelyn and Bootman, Martin D. (2006). New Ca2+ indicator has freedom to express. Chemistry & Biology, 13(5) pp. 463–464.



The application of synthetic calcium-chelating indicator dyes to monitor intracellular calcium concentration has provided great insight into the signaling pathways that give rise to changes in intracellular calcium as well as those that are affected by them. Furthermore, they have opened a window onto the intricate temporal and spatial dynamics of intracellular calcium that occur in response to a given stimulus. Without these tools, many of the fundamental signaling mechanisms required for the normal functioning of our cells and organs, such as the consolidation of memory and regulation of the heart beat, would not have been elucidated. Using different experimental conditions, these dyes can be used to measure calcium in intracellular organelles including the ER and mitochondria. However, specific methods usually have to be adopted for each dye and cell type, and the distribution of the dye is not always faithful.

Viewing alternatives


Public Attention

Altmetrics from Altmetric

Number of Citations

Citations from Dimensions

Item Actions