Cell signalling: IP₃ receptors channel calcium into cell death

Hanson, C. Jane; Bootman, Martin D. and Roderick, H. Llewelyn (2004). Cell signalling: IP₃ receptors channel calcium into cell death. Current Biology, 14(21) R933-R935.

DOI: https://doi.org/10.1016/j.cub.2004.10.019

Abstract

There is substantial evidence that Ca²⁺ fluxes occur during most forms of apoptosis, and that inhibiting such fluxes protects cells from death. IP₃ receptors – ligand-gated channels that release Ca²⁺ from intracellular stores – are emerging as key sites for regulation by pro- and anti-apoptotic factors.

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