Calcium signalling: dynamics, homeostasis and remodelling

Berridge, Michael J.; Bootman, Martin D. and Roderick, H. Llewelyn (2003). Calcium signalling: dynamics, homeostasis and remodelling. Nature Reviews Molecular Cell Biology, 4(7) pp. 517–29.

DOI: https://doi.org/10.1038/nrm1155

Abstract

Ca²⁺ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. An extensive Ca²⁺-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics. Rapid highly localized Ca²⁺ spikes regulate fast responses, whereas slower responses are controlled by repetitive global Ca²⁺ transients or intracellular Ca²⁺ waves. Ca²⁺ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.

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