Why, where, and when do cardiac myocytes express inositol 1,4,5-trisphosphate receptors?

Bootman, Martin D. and Roderick, H. Llewelyn (2008). Why, where, and when do cardiac myocytes express inositol 1,4,5-trisphosphate receptors? American Journal of Physiology. Heart and Circulatory Physiology, 294(2) H579-H581.

DOI: https://doi.org/10.​1152/​ajpheart.​01378.​2007

Abstract

The sequence of events leading to a Ca²⁺ signal during cardiac excitation-contraction (EC) coupling is well known. With each beat, the propagating action potential depolarizes the sarcolemma of the excitable myocytes within the heart. Membrane depolarization leads to the activation of voltage-operated Ca²⁺ channels (VOCs), thereby causing a brief influx of Ca²⁺. The Ca²⁺ influx is sensed and amplified by Ca²⁺ release channels known as ryanodine receptors (RyRs), which are expressed on the sarcoplasmic reticulum (SR) in close apposition to the VOCs. The RyRs are activated by the Ca²⁺ permeating across the VOCs via a process known as Ca²⁺-induced Ca²⁺ release (CICR).

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