Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca²⁺ signaling and disease

Distelhorst, Clark W. and Bootman, Martin D. (2011). Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca²⁺ signaling and disease. Cell Calcium, 50(3) pp. 234–41.

DOI: https://doi.org/10.1016/j.ceca.2011.05.011

Abstract

The Bcl-2 protein, best known for its ability to inhibit apoptosis, interacts with the inositol 1,4,5-trisphosphate receptor (IP₃R) Ca²⁺ channel to regulate IP₃-mediated Ca²⁺ release from the endoplasmic reticulum. This review summarizes the current state of knowledge regarding the interaction of Bcl-2, and also its homologue Bcl-xl, with the IP₃R and how these interactions regulate Ca²⁺ signaling. The dual role of these interactions in promoting prosurvival Ca²⁺ signals, while at the same time inhibiting proapoptotic Ca²⁺ signals, is discussed. Moreover, this review will elucidate the recently recognized importance of the Bcl-2-IP₃R interaction in human disease.

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